目的在氧嗪酸钾盐诱导小鼠产生高尿酸血症模型的基础上,探讨岩白菜素的抗高尿酸活性。方法将60只昆明种雄性小鼠随机均分为6组:正常对照组、高尿酸血症模型组、岩白菜素(20、40、60 mg/kg)组、别嘌呤醇(5 mg/kg)组。每天灌胃氧嗪酸钾盐(250 mg/kg)1 h后再灌胃给药,连续1周。分别测定血清中尿酸、肌酐和尿素氮水平,尿液中尿酸和肌酐水平,以及肾脏尿酸转运子1(mURAT1)和葡萄糖转运子9(mGLUT9)的mRNA和蛋白表达水平。结果与高尿酸血症模型组比较,岩白菜素显著降低高尿酸血症小鼠血清中尿酸、肌酐和尿素氮水平,提高24 h尿液尿酸和肌酐排泄量以及尿酸排泄分数,显著下调高尿酸血症小鼠肾脏mURAT1和mGLUT9的mRNA和蛋白表达水平。结论岩白菜素通过促进高尿酸血症小鼠肾脏尿酸排泄作用及逆转尿酸转运体的过度表达,从而体现抗高尿酸活性。

Objective To explore the anti-hyperuricemia activity of bergenin in the model of hyperuricemic mice induced by potassium oxonate. Methods 60 Kunming male mice were divided randomly into six groups, which were normal control group;hyperuricemic model group;and hyperuricemic groups with 20 , 40 , 60 mg/kg berge-nin, and 5 mg/kg allopurinol. Mice were orally administered once daily with 250 mg/kg potassium oxonate for 7 continuous days to create the model, and then three doses of bergenin and allopurinol were orally initiated on the day 1 h after potassium oxonate was given, separately. Serum uric acid, creatinine and urea nitrogon levels, as well as urinary uric acid and creatinine levels were measured. mRNA and protein expression levels of mouse kidney u-rate transporter 1(URAT1), and glucose transporter 9(GLUT9) were also determined. Results Compared with hyperuricemic model group, bergenin significantly reduced serum uric acid, creatinine and urea nitrogon levels, in-creased 24 h uric

目的：研究某部干部血尿酸及肾脏排泄尿酸变化的影响因素，查找尿酸升高的可能危险因素，为控制尿酸提供指导依据。方法利用年度干部体检对某部参加体检的非痛风和尿酸未受明确因素影响的1096人进行问卷调查，及血生化等检查，并计算体质指数、尿白蛋白肌酐比、尿酸-肌酐廓清率比值。以男性血尿酸＞420μmol/L（7.0 mg/dL）、女性血尿酸＞357μmol/L（6.0 mg/dL）为高尿酸血症组，余为非高尿酸血症组；以尿酸-肌酐廓清率比值由低到高分为尿酸低排组、混合组和尿酸高排组。汇总数据后进行统计学分析。结果男性血尿酸明显高于女性[（330.9±69.4）mmol/L 与（249.4±55.2）mmol/L）]；高尿酸血症患病率男性与女性无明显差别。高尿酸血症组体质指数、收缩压、舒张压、三酰甘油、血肌酐、尿素氮、高敏 C 反应蛋白、同型半胱氨酸、尿白蛋白肌酐比、腰围、臀围均明显高于非高尿酸血症组，而高密度脂蛋白、尿酸-肌酐廓清率比值明显低于非高尿酸血症组。高尿酸血症与体质指数、三酰甘油、血肌酐、高敏 C 反应蛋白、尿白蛋白肌酐比、尿酸-肌酐廓清率比值密切相关，其中尿酸-肌酐廓清率比值、三酰甘油、体质指数为重要影响因素。血尿酸与三酰甘油、体质指数、腰围、臀围、舒张压

Objective To study the influencing factors of serum uric acid levels and uric acid excretion in the officers at a military unit, in order to search the potential risk factors corre-sponding to the elevation of serum uric acid, and provide guidance to the control of uric acid levels. Methods In 1 096 cases, a questionnaire survey was provided for the retired officers in the military unit.Based on predefined inclusion and exclusion criteria, healthy officers or officers who took no drugs affecting uric acid metabolism were selected.Body mass index (BMI), urinary albumin creati-nine ratio (ACR) and uric acid to creatinine clearance rate (Cua/Ccr) were measured, and the data was analyzed.Results Men had higher serum uric acid levels compared with women [(330.9± 69.4)mmol/L vs.(249.4±55.2) mmol/L].There was no significant difference in the prevalence of hyperuricemia (HUA) between men and women (8.7% vs.5.6%).HUA group had higher BMI, systolic blood pressure, diastolic blood pre

全球多项研究显示，高尿酸血症是缺血性脑卒中的独立危险因素之一，血尿酸水平升高可增加脑卒中的发生率和死亡率。高尿酸血症与缺血性卒中的危险因素（高血压、糖尿病、高血脂、动脉粥样硬化等）共同促进缺血性脑卒中的发生。对高尿酸血症的治疗已经从急性期治疗转变为强调长期控制血尿酸达标，预防各种合并症。高尿酸血症的治疗包括调整饮食结构、改变生活方式、积极控制与血尿酸升高相关的危险因素、避免应用血尿酸升高的药物、碱化尿液等。降低血尿酸的药物包括增加尿酸排泄的药物、抑制尿酸合成药物、辅助降尿酸药。如果引起血尿酸增高的原因不能去除，需要长期降尿酸治疗。

Several studies have shown the hyperuricemia(HUA) is independent of risk factor for ischemic stroke, elevated serum uric acid levels can increase the incidence of stroke and mortality of patients with hyperuricemia. Hyperuricemia and risk factors for ischemic stroke, such as high blood pressure, diabetes, hyperlipidemia, atherosclerosis, etc, jointly promote the occurrence of ischemic stroke. The control of hyperuricemia has been changed ,which was from the acute phase treatment to emphasis on long-term control of the urine and preventing various complications. The treatment of hyperuricemia includes adjusting the diet structure, changing lifestyle, control ing serum uric acid-related metabolic risk factors aggressively, avoiding use of drugs which could increase serum uric acid, and alkaline urine. The drugs which can reduce the blood uric acid including drugs that increased uric acid excretion, inhibited uric acid synthetic, and auxiliary drugs. If the causes of elevated serum uric a

目的 探讨尿酸排泄分数与原发性痛风患者血尿酸、体质量指数(BMI)、血压、血糖以及血脂等代谢因素的相关性.方法 选择62例原发性痛风患者为痛风组和32例健康体检者为对照组,痛风组患者按尿酸排泄分数水平分为尿酸排泄减少组29例(尿酸排泄分数＜7％)、混合组25例(7％≤尿酸排泄分数≤12％)和尿酸生成增多组8例(尿酸排泄分数＞12％).抽取患者空腹血,检测血肌酐、血尿酸、血糖、糖化血红蛋白及血脂水平,留取24h尿,测得24 h尿尿酸、尿肌酐,根据公式计算尿酸排泄分数并进行相关性分析.结果 痛风组BMI、平均动脉压、血尿酸、糖化血红蛋白、总胆固醇、餐后2h血糖明显高于对照组,高密度脂蛋白胆固醇、尿酸排泄分数明显低于对照组,差异有统计学意义(P＜0.05);两组年龄、空腹血糖、低密度脂蛋白胆固醇、三酰甘油比较差异无统计学意义(P＞0.05).尿酸排泄减少组、混合组、尿酸生成增多组年龄、血尿酸、空腹血糖、餐后2h血糖、糖化血红蛋白、总胆固醇、低密度脂蛋白胆固醇、高密度脂蛋白胆固醇比较差异无统计学意义(P＞0.05);三组BMI、平均动脉压、三酰甘油、尿酸排泄分数比较差异有统计学意义(P＜0.05).对照组和痛风组,尿酸排泄分数与血尿酸均呈负相关(r=-3.900,-0.476,P＜0.05).

Objective To study the correlation between fractional excretion of uric acid (FEUA) and blood uric acid,body mass index (BMI),blood pressure,blood glucose,blood lipid and other metabolic factors in patients with primary gout.Methods Sixty-two patients with primary gout (gout group) and 32 healthy people (control group) were selected in this study.Gout group was divided into uric acid excretion decreasing group (FEUA ＜ 7％,29 cases),mixed group (7％ ≤FEUA ≤ 12％,25 cases) and uric acid production increasing group (FEUA ＞ 12％,8 cases) according to the level of FEUA.The fasting blood glucose (FPG),2-hour postprandial blood glucose (2 h PBG),blood lipid,serum creatinine,blood uric acid,glycosylated hemoglobin were tested.24 hours urine was collected and urinary uric acid and urinary creatinine was measured,FEUA was calculated and analyzed.Results BMI,mean arterial pressure,blood uric acid,glycosylated hemoglobin,total cholesterol,2 h PBG in gout group was higher than that in

了解高尿酸血症在不同性别体检人群的患病情况,探讨高尿酸血症与尿pH值的相关性。方法:通过对体检人群的检查结果进行总结,分析比较高尿酸血症组与非高尿酸血症组性别患病情况、尿pH值差异。结果:本次调查高尿酸血症患病率为8.71%,男性患病率高于女性,高尿酸血症组尿pH值低于非高尿酸血症组。结论:高尿酸血症具有较高患病率,与尿pH值关系密切。

Objective:To understand the prevalence of hyperuricemia in different gender in health examination,investigate the relationship between hyperuricemia and urinary pH value.Methods:Through summing up the physical examination among the inspection results,analysis and comparison of hyperuricemia group and non hyperuricemia group sex prevalence,urine pH value difference.Results:The hyperuricemia prevalence rate of this survey was 8.71%,male was higher than female, the urine pH value of hyperuricemia group is lower than the non hyperuricemia group.Conclusion:Hyperuricemia has a high prevalence,and has close relationship with urinary pH value.