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双语推荐：拜新同

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目的：探讨分析拜新同联合应用小剂量倍他乐克治疗中青年高血压的临床疗效。方法选取2011年12月～2013年12月收治的107例中青年高血压患者为研究对象，将其用数字表法随机分成两组，观察组57例患者给予拜新同联合小剂量倍他乐克治疗，对照组50例患者给予拜新同治疗，观察两组临床疗效。结果观察组患者总有效率为98.2％，显著高于对照组86.0％，差异具有统计学意义（P＜0.05）；两组患者舒张压（DBP）、收缩压（SBP）及心率（HR）改善情况均优于治疗前，观察组改善情况显著优于对照组，差异具有统计学意义（P＜0.05）。结论拜新同联合应用小剂量倍他乐克治疗中青年高血压的临床疗效较显著，能有效提高患者生活质量。
Objective The clinical efficacy of Adalat combination of low -dose metoprolol treatment of hypertension young.Methods Choose Dec.2011 Dec.2013 in our hospital 107 cases of young hypertensive patients for the study were randomly divided into two groups , the study group of 57 patients given low dose Adalat metoprolol treatment , the control group of 50 Adalat patients given treatment , clinical efficacy.Results The patients total effective rate was 98.2%, significantly higher than 86.0%, the difference was statistically significant ( P<0.05 );groups of patients di-astolic blood pressure (DBP), systolic blood pressure (SBP) and heart rate (HR) to improve the situation are better than before treatment , improvement in the observation group were significantly better than the control group , the differ-ence was statistically significant ( P<0.05 ).Conclusions Adalat clinical efficacy combined with a small dose of meto-prolol in the treatment of hypertension significantly young , can effecti

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探讨中药生脉注射液联合硝苯地平缓释片(拜新同)在高血压病治疗中的临床效果评价。方法:选择临床诊断的高血压病患者40例为研究对象,采用口服拜新同治疗,8周为1个疗程。在此治疗基础上应用中药生脉注射液治疗,40m L/次,加生理盐水250m L,静脉滴注,1次/d,疗程7d。于治疗前、后测定其血压和记录头晕、头痛、失眠等症状,并进行比较。结果:治疗前后收缩压分别是(155.000±7.663)mm Hg和(128.333±3.904)mm Hg(P0.01),而舒张压治疗前后分别是(99.700±7.040)mm Hg和(85.900±7.824)mm Hg,(P0.01);主要症状治疗前后秩均值分别是22.95和63.54,经比较,P0.01。结论:生脉注射液联合硝苯地平缓释片治疗高血压病疗效确切,作用持久缓和,能明显降低收缩压及舒张压,是理想的治疗高血压的长效制剂。
Objective: To investigate clinical effective evaluation of the Shengmai injection combined with extended release nifedipine tablets (Nifedipine GITS) on hypertension. Methods:40 patients with hypertension in clinic were selected as the research object, and all were given Nifedipine GITS orally, 8 weeks as 1 course. All patients were added the Shengmai injection more, 40 mL each time, and plus normal saline 250mL, intravenous drip, 1 time per day, course for 7d. The blood pressure and record the determination of dizziness, headache, insomnia and other symptoms before and after treatment were compared. Results:Before and after treatment, systolic pressures were (155.000±7.663) mmHg and (128.333±3.904) mmHg (P<0.01);and diastolic blood pressure before and after treatment, respectively (99.700±7.040) mmHg and (85.900±7.824) mmHg (P<0.01);before and after treatment, rank values of the main symptoms were 22.95 and 63.54, by comparison, P<0.01. Conclusion:The Shengmai injection

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患者男性,76岁,因“头晕、头痛20余年,无尿2年,发热7d”于2012年10月28日入吉林大学第二医院肾病内科就诊,诊断为“高血压病3级,慢性肾功能不全-尿毒症期,肺部感染”.既往有脑梗塞病史3年,卧床2年,偶有进食呛咳.在肾病科住院期间给予联合口服降压药(拜新同、代文、络德)、血液透析、抗感染等对症支持治疗.在系统治疗过程中突然出现抽搐,意识不清,血氧饱和度下降至60％,考虑肺部感染、痰阻气道引起急性呼吸衰竭,经口气管插管后转入综合ICU病房.入ICU时浅昏迷状态,经皮脉氧饱和度91％.左肺呼吸音弱,右肺可闻及痰鸣音.
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对比厄贝沙坦片和硝苯地平控释片的降压效果及对高血压患者血压晨峰的影响。方法:高血压患者90例,随机分配为厄贝沙坦片组(A组)和硝苯地平控释片组(B组)各45例,分别给予厄贝沙坦片150 mg/d和硝苯地平控释片30 mg/d,降压治疗4周,对比两组治疗前后舒张压(DBP)、收缩压(SBP)、平均动脉压(MAP)及血压晨峰(MBPS)的变化。结果:两组患者治疗4周后DBP、SBP均有下降(P0.05),B组下降程度较A组明显(P0.05),B组MBPS较A组下降显著(P0.05)。结论:硝苯地平控释片(拜新同)降低血压、预防血压晨峰的效果优于厄贝沙坦片(安博维)。
Objective To evaluate the effect of irbesartan and nifedipine controlled-release tablets on morning blood pressure surge in patients with essential hypertension. Methods Ninety patients with essential hypertension were randomly divided into irbesartan group ( group A, n = 45) and nifedipine group (group B, n =45). Irbesartan tablets 150 mg/d and nifedipine controlled-release tablets 30 mg/d were respectively given in group A and group B for 4 weeks. The levels of diastolic blood pressure (DBP), systolic blood pressure (SBP), mean arterial pressure ( MAP ) and morning blood pressure surge ( MBPS ) before and after treatment were measured by ambulatory blood pressure monitoring. Results The DBP, SBP, MAP and MBPS levels of two groups after treatment for 4 weeks were all decreased (P < 0.01). All the indexes of group B decreased more significant compared to group A (P < 0.05 ). Conclusion To control blood pressure and prevent morning blood pressure surge, nifedipine controlled-release tab

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目的观察硝苯地平控释片(拜新同)对老年原发性高血压患者血压变异性(BPV)及血清胱抑素C(Cys-C)水平的影响。方法选取医院老年原发性高压患者62例,随机分为对照组30例及治疗组32例,治疗组予硝苯地平控释片治疗;对照组给予安慰剂作为对照。用药后第2周末做动态血压监测及检测血清胱抑素C的含量,观察BPV及其对早期肾功能的影响。结果治疗组的收缩压变异性和舒张压变异性均较对照组有明显下降,血清Cys-C含量明显降低,差异均有统计学意义(P0.05)。24h血压变异性与血清Cys-C含量呈显著正相关,血压变异性与高血压性肾脏损害密切相关。结论硝苯地平控释片可有效降低老年原发性高血压患者的血压变异性,同时降低血清Cys-C水平,对肾脏具有一定的保护作用。
Objective To observe the effects of nifedipine controlled release tablet on blood pressure variability ( BPV)and the serum levels of Cys-C of eldly patients with primary hypertension. Methods 62 cases of eldly patients with primary hypertension were randomly divided into control group(30 cases)and treatment group(32 cases). The treatment group was given nifedipine controlled release tablet for treatment,while the control group was given placebo. After two weeks, the BPV was measured by blood pressure monitoring,and the serum levels of Cys-C were examined. Observe the BPV and its influence on the early renal function. Results Compared with control group,the blood variability of systolic and diastolic blood pressure was decreased significantly in treatment group,and the serum levels of Cys-C was decreased,the differences were statistically significant(P<0. 05). The indexe of BPV was significant positive correlation with the levels of Cys C. The Blood pressure variability of hypertensive

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