登录

双语推荐：生殖激素

进入期刊文章
kisspeptin是调控女性生殖内分泌功能的重要肽类激素,大量的研究表明,kisspeptin可以通过介导雌二醇的正负反馈调节促性腺激素释放激素(gonadotropin-releasing hormone,GnRH)的分泌,继而参与调节生殖系统的发育、性激素的分泌及维持下丘脑-垂体-卵巢(HPO)轴的稳定.kisspeptin在体内的调控涉及诸多方面,如促进GnRH分泌、激发青春期启动、影响性分化等.本文从kisspeptin的结构、分布、与生殖内分泌的关系进行综述,并重点讨论kisspeptin在生殖内分泌方面的研究进展.
@@

[ 可能符合您检索需要的词汇 ]

进入期刊文章
激素敏感性脂肪酶被认为是经典的脂肪分解限速酶，可特异水解甘油三酯，受儿茶酚胺等激素调控。近年来研究表明：HSL 作用底物不仅有甘油三酯，还包括甘油二酯、甘油一酯、胆固醇酯等。然而，脂肪酶在生殖系统的功能并不清楚，基因敲除小鼠为证实 HSL 广泛存在于生殖系统提供良好模型，提示其可能在生殖系统生理及病理生理过程发挥重要调节作用，本文将着重介绍生殖系统中 HSL 基因与蛋白质结构并总结其在生殖系统的功能。
Hormone-sensitive lipase (HSL)has long been considered as a classical rate-limiting enzyme during lipolysis since it was first described in 1 960s.HSL is regulated mainly by catecholamine,inclu-ding adrenalin.Studies in recent years indicated that the substrates for HSL are not only triglycerides, but also diacylglycerol with the catalytic activity is ten times that of triglycerides,glycerol esters and cho-lesterol esters,which overthrow the opinion that HSL is specific to triglyceride.The scientists have gener-ated HSL gene knockout mice and confirmed HSL is widely located in the reproductive system,which in-dicates that HSL may play an important role in the regulation of physiological and pathophysiological process in the reproductive system.Here,we will focus on the features of the HSL gene,mRNA and its protein,and summarize the HSL functions in the reproductive system.

[ 可能符合您检索需要的词汇 ]

进入期刊文章
现代内分泌系统的概念已涉及几乎全身组织或细胞。下丘脑促性腺激素释放激素（GnRH）-促性腺激素（Gn）脉冲分泌激活是启动卵巢轴功能的关键。其与4个下丘脑内分泌系统存在复杂的联系。神经内分泌免疫网络、神经内分泌营养调节网络也影响GnRH-Gn脉冲分泌或卵巢配子生成及性激素合成。介绍全身主要内分泌疾病对女性生殖的影响，并通过介绍一个心理神经内分泌失调疾病---功能性下丘脑性无排卵（functional hypothalamic anovulation，FHA），阐述应激对全身及女性生殖的影响。
The modern endocrine system has been conceptually expanded to almost all tissues or cells of human body. Activation of the pulsatile secretion of hypothalamic GnRH-Pituitary Gn is the key step of initiating ovarian function, which is related to other four hypothalamic endocrine systems. Both the neuroendocrine-immune network and neuroendocrine-nutrition regulating network also impact the GnRH-Gn pulsatile secretion or ovarian gametogenesis, as well as steroidogenesis. This paper discussed the influence of systemic endocrine diseases on female reproduction,and elucidated the effects of stress on the systemic endocrine organs and ovarian axis by a psychoneuroendocrine disorder, functional hypothalamic anovulaton.

[ 可能符合您检索需要的词汇 ]

进入期刊文章
促性腺激素释放激素（GnRH）最初被认为是一种下丘脑神经肽，但是越来越多的研究发现该激素具有多重功能，如参与类固醇生成、细胞增殖、受精、粘连细胞外基质和细胞迁移等生理功能的调节，并在动物的生长发育、生殖行为、妊娠、分娩等生命活动中起着至关重要的作用。主要对GnRH的结构特点及其调控进行了综述。
Gonadotropin-releasing hormone (GnRH) is firstly taken as a kind of hypothalamic neuropeptide, but more and more researches show that GnRH has multiple functions, such as participating in the regulation of generation of steroids, cell proliferation, fertilization, adhesion of extracellular matrix, cell migration, etc., and also plays a crucial role in the growth, reproductive behavior, pregnancy and delivery of animals. The structure and regulation of GnRH were summarized.

[ 可能符合您检索需要的词汇 ]

进入期刊文章
多囊卵巢综合征(polycystic ovary syndrome,PCOS)是年轻妇女最常见的内分泌疾病,也是引起妇女体内雄激素过多的常见原因,发生率约占生育年龄妇女的5%~10%,其临床表现和生化特征多样化,主要是由于雄激素过多引起的一系列严重内分泌、代谢、生殖和心血管系统紊乱症状。众所周知,高雄激素血症是PCOS的主要生化特征,且PCOS患者雄激素的发生机制复杂,正确认识并防治高雄激素血症成为治疗PCOS的关键。下面就PCOS雄激素的形成机制有关研究进行综述。
Polycystic ovary syndrome(PCOS)is the mostcom monendocrine disease among young women,which is also a common cause of excessive androgens in women with the incidence rate ranging from 5% to 10% among the child bearing-age women .It has diversified clinical and biochemical characteristics,mainly including a series of serious disorders in internal secretion ,supersession ,reproduction ,and cardiovascular system due to excessive androgen .As is known to all,hyperandrogenism is the main biochemical characteristics of polycystic ovary syndrome,and the androgenic mechanism is complex for PCOS sufferers,so the correct understanding for the prevention and treatment of hyperandrogenism has become the key to the treatment of polycystic ovary syndrome.The paper summarizes the relevant research on the form ation mechanism of androgen in PCOS .

[ 可能符合您检索需要的词汇 ]

进入期刊文章
目的：研究内分泌及免疫紊乱与复发性流产的相关性。方法：2014年1-6月收治复发性流产患者30例，作为试验组，选择40例健康者作为对照组。对两组自身免疫抗体、细胞因子、生殖激素水平及子宫内膜免疫组化检测并比较。结果：试验组中免疫抗体阴性24例，免疫抗体阳性6例。试验组中均存在内分泌失调，出现单项或多项生殖激素异常。试验组子宫内膜ICAM-1阳性。结论：女性内分泌及免疫紊乱在复发性流产中可以并存，对复发性流产的患者进行生殖激素和自身免疫抗体检测具有重要诊断价值。
Objective:To study the correlation between endocrine and immune dysfunction and recurrent spontaneous abortion. Methods:30 patients with recurrent spontaneous abortion were selected from January to June 2014 as the experimental group.40 healthy people were selected as the control group.The autoimmune antibodies,cytokines,reproductive hormone level and endometrial immunohistochemical of two groups were detected and compared.Results:In the experimental group,24 cases of immune antibody were negative;6 cases of immune antibody were positive.In the experimental group,the patients all had endocrine dyscrasia,and single or multiple abnormal reproductive hormones.The endometrium ICAM-1 of the experimental group was positive.Conclusion:Female endocrine and immune dysfunction can coexist in recurrent spontaneous abortion.The reproductive hormones and immune antibody detection in the patients with recurrent spontaneous abortion has important diagnostic value.

[ 可能符合您检索需要的词汇 ]

进入期刊文章
目的观察动脉瘤性蛛网膜下腔出血（aSAH）患者康复期腺垂体激素水平变化，探讨其垂体功能不全发生率及发生类型。方法选取aSAH患者47例，出血后12个月行GOSE评分评估预后，同期应用化学发光免疫分析法检测患者生长激素（GH）、促肾上腺皮质激素（ACTH）、促甲状腺素（TSH）、生殖激素[血清泌乳素（PRL）、促卵泡生成素（FSH）、促黄体生成素（LH）、雌二醇及睾酮]。结果 GOSE评分预后良好32例，预后不良15例(死亡2例)。预后良好的32例患者中腺垂体激素水平异常者13例（40.6%），其中单纯GH、ACTH、TSH及生殖激素水平低下分别为4、1、1、4例，GH合并生殖激素低下2例，GH合并ACTH低下1例；预后不良13例患者中腺垂体激素水平异常者6例（46.2%），其中单纯GH、ACTH及生殖激素水平低下分别为2、1、1例，GH合并生殖激素低下1例，GH合并ACTH低下1例。预后良好患者与不良患者腺垂体激素水平异常发生率的差异无统计学意义（P＞0.05）。结论 aSAH患者康复期垂体功能不全发生率较高，以单一激素水平低下为主，表现为疲劳困倦、记忆力下降、抑郁等神经精神症状，但不影响神经功能预后。
Objective To investigate the prevalence of hypopituitarism fol owing aneurismal subarachnoid hemorrhage (aSAH) in chronic stage. Methods Prospective cohort study was performed in 47 patients with aSAH. Twelve months after aSAH, the fol ow- up prognosis was evaluated by GOSE score (Glasgow Outcome Scale- Extended score) and testing major an-terior pituitary hormones. Results According to GOSE score, patients were classified into good outcome group (n=32) and poor outcome group (n=15, including 2 deaths). In good outcome group the hypopiruitarism developed in 13 cases (40.6%), including GH deficiency (4 cases), corticotroph deficiency (1), hypothyroidism (1) and hypogonadism (4), and GH deficiency with hypogo-nadism (2) or corticotroph deficiency (1). In poor outcome group abnormal pituitary hormones were detected in 6 patients (46.2%), including GH deficiency (2 cases), corticotroph deficiency (1), and hypogonadism (1), GH deficiency accompanied by hypogonadism (1) or corticotroph defic

[ 可能符合您检索需要的词汇 ]

进入期刊文章
目的：探讨附子提取物对雌性大鼠生殖毒性的影响。方法附子提取物给大鼠连续灌胃30 d,考察脏器指数、动情期观察、生殖激素含量变化。结果附子提取物造成雌性大鼠动情周期紊乱,脏器指数明显下降,性激素：卵泡刺激素（FSH）、黄体生成素（LH）、雌二醇（E2）、孕酮（P）含量较阴性对照组均显著下降。结论附子提取物的生殖毒性作用可能与FSH、LH、E2、P含量下降有关,提示提高性激素水平,可有助于降低附子提取物的生殖毒性。
Objective To investigate the influence of extractive of monkshood on the reproductive toxicity of female mice. Methods Gavages to mice was applied continuously for 30 days with extractive of monkshood. The organ index, estrus cycle, and change of reproductive hormone were investigated. Results The extractive of monkshood caused disorders of estrous cycle and obvious decline of visceral index. Contents of sex hormones, such as follicle-stimulating hormone (FSH), luteinizing hormone (LH), estradiol (E2), and progesterone (P) were significantly decreased compared with negative control group. Conclusion The reproductive toxicity of extractive of monkshood may have relation with decreased contents of FSH, LH, E2, and P. Increasing the level of sex hormone can be helpful in decreasing the reproductive toxicity of extractive of monkshood.

[ 可能符合您检索需要的词汇 ]

进入期刊文章
本文简要综述了褪黑激素(MT)对动物繁殖活动的影响,并总结了MT调控动物生殖的作用位点及途径,便于进一步揭示MT调节动物繁殖的本质。
In this article ,effects of melatonin on animal reproduction were summarized and the mechanism of action ,in which melatonin regu-lates animal reproduction was reviewed to reveal the nature of melatonin regulating animal reproduction .

[ 可能符合您检索需要的词汇 ]

进入期刊文章
目的：探讨男性无精症、少精症患者与健康人群血清生殖激素之间的关系。方法：利用全自动化学发光分析技术测定108例无精、50例男性少精不育症患者的血清FSH、LH、E2、T、PRL,并与25例正常人对比。结果：无精症组生殖激素较正常人明显增高,以FSH升高尤著;少精症组FSH也明显升高。E2、T、PRL在少精症组和正常人群间无显著性差异。结论：男性少精、无精症在内分泌方面与生殖激素水平表达有密切关系。
Objective:To discuss the difference between the patients with azoospermia or oligospermia and healthy people in serum reproductive hormone. Methods:With automatic chemiluminescence analysis technology,determined 108 cases of azoospermia,50 cases of oligozoospermia male infertility patients’serum FSH,LH,E2,T,PRL concentration. Results:In azoospermia cases,FSH,LH was significantly higher than normal people;and elevated FSH was bigger than LH;In azoospermia cases,FSH,PRL also increased significantly. E2,T,PRL was no significant difference between azoospermia and normal population. Conclusion:The endocrine and expression of reproductive hormone levels are closely related in male oligospermia or azoospermia.

[ 可能符合您检索需要的词汇 ]