背景：抗炎活血解痉中药具有修复肾脏组织，改善肾脏血液供应，降低肾小球毛细血管的通透性，增强肾小管的滤过功能的作用。 目的：探讨模拟4000 m高住及抗炎活血解痉中药对4周力竭运动大鼠肾细胞超微结构及α-平滑肌肌动蛋白表达的影响。 方法：将大鼠在速度为10 m/min坡度为0的跑台上进行适应性跑15 min，筛选出32只能完成跑的大鼠，随机分为正常对照组、力竭运动组、高住力竭运动组和给药力竭运动组，每组8只。正常对照组不进行运动，其他3组均进行力竭运动。高住力竭运动组模拟4000 m高住后再进行力竭运动；给药力竭运动组先给予抗炎活血解痉中药灌胃，再进行4周力竭运动。采用苏木精-伊红染色、透射电子显微镜观察各组大鼠肾细胞的超微结构，免疫组织化学法检测肾组织α-平滑肌肌动蛋白的表达。 结果与结论：力竭运动组可出现慢性肾损伤，肾小球滤过膜3层超微结构破坏，肾小管间质大量纤维化改变。与力竭运动组相比，高住力竭运动组和给药力竭运动组大鼠的运动量(跑距)增强(P <0.05)，肾超微结构的损伤有明显的改善，α-平滑肌肌动蛋白的表达显著下降(P <0.01)。结果证实，抗炎活血解痉中药灌胃与模拟4000 m高住干预对4周力竭运动诱导的肾超微结构损伤起保护作用

BACKGROUND:Chinese herb for anti-inflammation, blood circulation promotion and spasmolysis can repair the kidney, supply renal blood, reduce the permeability of the glomerular capil aries, and enhance renal filtration function.OBJECTIVE:To explore the effects of a Chinese herb for anti-inflammation, blood circulation promotion and spasmolysis on ultrastructure of renal cells and a-smooth muscle actin in rats after 4-week exhaustive exercise living at simulated altitude of 4 000 meters. METHODThirty-two rats which could complete 15-minute adaptive run on the treadmil at a speed of 10 m/min were enrol ed and randomized into normal control group, exhaustive exercise group, exhaustive exercise+high-altitude group and exhaustive exercise+Chinese herb group, eight rats in each group. Except the normal control group, rats in the other three groups were subjected to exhaustive exercise, living at simulated altitude of 4 000 meters fol owed by exhaustive exercise, and intragastric adm

研究胃消颗粒治疗胃痛胃痉挛的作用。方法:以大鼠的离体胃肠平滑肌条为模型,考察胃消颗粒对大鼠胃肠平滑肌条收缩状况;以醋酸所致小鼠扭体反应为疼痛指标,观察胃消颗粒的镇痛作用;以角叉菜胶致大鼠足跖肿胀炎症模型考察胃消颗粒抗炎作用。结果:胃消颗粒显著促进大鼠胃肠平滑肌条的运动,200-280mg·ml-1浓度范围内可抑制大鼠胃肠平滑肌条的运动;胃消颗粒明显抑制小鼠扭体反应,明显抑制角叉菜胶致大鼠足跖肿胀。结论:胃消颗粒对大鼠胃肠平滑肌条的收缩具有双向调节作用,具有明显的抗炎镇痛作用。

Objective:To study the action of Weixiao granule on gastralgia and gastrospasm. Methods:Isolated rat intestine was selected in the assay to test the effects of Weixiao granule on contractilty of isolated rat gastric and intestine smooth muscle strips;With acetic acid induced mice writhing response model,analgesic effect of Weixiao granule was deterrmined.;The anti-inflammatory activity was evaluated with the circumference of rat ankle joint induced by carrageenin. Results:Weixiao granule could significantly improved the contractility of rat gastric and intestine smooth muscle strips.But Weixiao granule(200-280 mg·ml-1) could reduce the contractility of rat gastric and intestine smooth muscle strips. The results showed Weixiao granule exhibited analgesic effect on acetic acid induced mice writhing response model,and markedly suppressed the circumference of rat ankle joint induced by carrageenin. Conclusion:These results suggest Weixiao granule maybe has dual regulation on the

功能性消化不良（Functional Dyspepsia，FD）是针灸临床常见的消化系疾病和多发病。近年来大量的临床实践和动物实验证实了针刺对胃肠运动具有良好的调节作用，但其作用机制目前尚不十分清楚，文章从神经系统和胃肠激素这方面就针刺对胃运动作用的机制和调节作一论述。

Functional dyspepsia is a common digestive disease in acupuncture clinic. In recent years, a large number of clinical practice and animal experiments confirmed that acupuncture shows good regulation effects on gastrointestinal motility, but its mechanism still unclear. Based on nervous system and gastrointestinal hormones, effects of acupuncture were reviewed in this paper.

探讨高效氯氰菊酯对雄性小鼠精子运动的影响。方法:择体重为25~35g健康清洁级小鼠60只,随机分为6组,每组10只,设高、中、低三个剂量组,溶剂组、空白对照组(生理盐水)和环磷酰胺阳性对照组。除环磷酰胺阳性对照组小鼠外,其余各组小鼠均按0.2ml/10g灌胃给药5d,于染毒后7d、14d分两批处死,用40倍光镜下计数精子快速直线运动、慢呆直线运动,非向前运动,不动精子数量,每只小鼠计数完整的精子1 000条。结果:本次实验结果显示染毒14d后各实验组小鼠间精子快速、慢呆直线运动、非向前运动,不动比率,差别有统计学意义。结论:高效氯氰菊酯对小鼠精子的运动能力有影响。

Objective:To discuss effects of beta-cypermethrin on male mice sperm motility. Methods:60 g healthy ICR mice with the body weight of 25-35g were randomly divided into 6 groups: high, medium and low three dose groups, solvent group, blank control group (normal saline) and cyclophosphamide positive control group. Except cyclophosphamide positive control group, the other groups were given the drug at 0. 2ml/ 10g by gavage for 5 days, then killed 7d and 14d after the exposure. Through 40× light micro-scope, the numbers of sperm fast motion, slow motion to stay straight, non-moving forward, not moving sperm were recorded, and 1000 complete sperms of a mouse were involved. Results: This experiment showed that the difference of sperm fast motion, slow motion to stay straight, non-moving forward, not moving sperm among the six groups were statistically significant. Conclusions: Beta-cyper-methrin has effects on the sperm ability of the mice.

采用雄性 ICR 小鼠随机分组,分别灌胃蒸馏水、不同剂量的蛹虫草（Cordyceps militaris ）多糖（低、中、高剂量组分别每天灌胃75、150、450 mg/kg BW）,40 d 后建立疲劳模型,比较力竭游泳时间、肝肌糖原水平、乳酸含量和机体相关的乳酸脱氢酶和超氧化物歧化酶活力。结果表明：高剂量蛹虫草多糖能够显著延长小鼠力竭游泳时间,中高剂量多糖显著提高小鼠肝肌糖原水平,有效的遏制运动后小鼠乳酸生成量,而低剂量多糖显著增加运动后小鼠乳酸脱氢酶活力,3个剂量的多糖均能提高运动后小鼠血清中超氧化物歧化酶的活力。

A polysaccharide fraction obtained from Cordyceps militaris fruit bodies by hot water extraction (100 ℃,3 h),protein removal using the Sevag method,and ethanol precipitation was evaluated for anti-fatigue effects.Male ICR mice (96)were randomly divided into four equal groups,three of which wereadministered different doses (low dosage,75 mg/kg BW;medium dosage 150 mg/kg BW;high dosage 450 mg/kg BW)of polysaccharide daily for 40 days,and a control group given distilled water.At this point, the fatigue model was established by transferring the mice to a tank of water,and the effects of the polysaccharide fraction on the exhaustive swimming time,liver and muscle glycogen levels,blood lactic acid level,and serum lactate dehydrogenase (LDH)and superoxide dismutase (SOD)activities were determined. High dosages of C .militaris polysaccharide prolonged the exhaustive swimming time,and resulted in increased liver and muscle glycogen levels. However, lactic acid production was inhibite