目的：观察补肾活血开窍方治疗糖尿病所致血管性轻度认知功能障碍的临床疗效。方法：将30例糖尿病所致血管性轻度认知功能障碍的患者随机分为治疗组（15例）和对照组（15例），治疗组予以补肾活血开窍方（肉苁蓉10 g、石菖蒲5 g、三七2.5 g）免煎制剂治疗，每天3次，同时服用尼莫地平每次30 mg、一日3次，对照组服用尼莫地平每次30 mg、一日3次，上述治疗持续6个月。治疗前后采用临床痴呆评定量表（CDR）、日常生活能力量表（ADL）、蒙特利尔认知评估北京版（MoCA）及中医症候评分进行评估。结果：治疗后2组均有进步率，治疗组86.70%，对照组33.33%，治疗组总有效率优于对照组（P<0.05）。2组患者中MoCa量表和ADL量表及中医症候评分与同组治疗前比较，差异均有统计学意义（P<0.05），治疗组治疗后优于对照组，2组比较差异有统计学意义（P<0.05）。2组不良事件发生率比较经字2检验无统计学意义。结论：补肾活血开窍方治疗糖尿病所致血管性轻度认知功能障碍临床疗效优于尼莫地平，在改善日常生活能力、认知功能、痴呆程度及中医症候评分方面均优于尼莫地平；不良事件发生率与尼莫地平相当。

This study was aimed to observe clinical efficacy of Bushen Huoxue Kaiqiao (BSHXKQ) treatment of diabetes-induced vascular mild cognitive impairment . A total of 30 cases of diabetes-induced vascular mild cognitive impairment were randomly divided into the treatment group ( 15 cases ) and the control group ( 15 cas-es). The treatment group received free-fried BSHXKQ prescription (Cistanche 10 g, Shichangpu 5 g, Sanqi 2 . 5 g ) for treatment 3 times a day , and in combination of 30 mg of nimodipine , 3 times a day . In the con-trol group , 30 mg of nimodipine was orally administrated 3 times a day . The treatment was continued for 6 months. Clinical Dementia Rating (CDR), Activity of Daily Living Scale (ADL), Montreal Cognitive Assessment Beijing Edition ( MoCA ) and TCM Syndrome Score were used in the evaluation before and after the treatment . The results showed that the rate of progress was in both groups after treatment . In the treatment group , the rate was 86 . 70%, and in the co

阿尔茨海默病是一种原因未明的中枢神经系统原发性疾病，常起病于老年期或老年前期，本文从中医角度探讨其病机及治疗方法。阿尔茨海默病多表现为虚证，尤以气血两虚为主，病位虽然在脑，但其发病与脾、肾、肝、心的关系尤为密切。根据病证的不同，用补中益气汤健脾益气，用六味地黄汤补益肾精，用参苓白术散健脾祛痰祛邪扶正，用归脾汤补养气血，用加味逍遥丸疏肝健脾祛痰，用通窍活血汤以活血行气开窍，共同达到宣窍健脑的目的。

Alzheimers disease is a primary central nervous system disease,often seen in the senile and presenile.This paper discusses the pathogenesis and treatment methods from the viewpoint of traditional Chinese medicine.Alzheimers disease is manifested as a defi-ciency syndrome,especially Qi-blood deficiency.Although it is a disease with the brain,the cause is closely related to to heart,liver, spleen,kidney and brain.According to the different syndromes,Buzhong Yiqi Decoction is used for strengthening the spleen and replen-ishing qi,Six Ingredient Rehmannia Decoction is used for tonifying the kidney essence,Shenling Baizhu powder is used for expelling phlegm and expel pathogen,Guipi Decoction is used for enriching the blood and qi,Jiawei xiaoyao pill is used for soothing liver and invig-orating spleen and phlegm,Tongqiao huoxue Decoction to invigorate the circulation of blood and Qi obstruction.These treatments achieve the purpose ofreleasing orifices and strengthening brain.