It is necessary to carry out on-line verification to the relay settings based on the traditional off-line fault prediction method. Several key technologies of on-line verification are studied and proposed in this paper, including the EMS data acquisition, the forma-tion of real-time operation mode, connection with relay information system, verification calculation, and verification process, etc. On this basis and with the actual situation of Guangxi power grid, EMS based relay settings on-line verification system for Guangxi Power Grid is designed and developed, and its general idea and structure, hardware design and database design are presented. The feasibility and effectiveness of the proposed system are verified with a practical application.