The article, combining the steel box girder of ove-rpass engineering of Hou weizhai, analyzed the key construc-tion technology of large span steel box girder overpass, and the general situation of the project are briefly analyzed. According to the construction difficulties, the author determined the rat-ional thinking of construction, focusing on the technical probl-ems in welding and painting of the steel box girder, and ins-tal ation of the steel box girder.