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双语推荐:乳腺肿瘤

目的探讨乳腺肿瘤旋切系统旋切乳腺肿瘤活检对乳腺肿瘤的活检诊断效果,以及其在治疗乳腺肿瘤中的作用。方法对我院2008年1月至2013年1月63例86处乳腺肿瘤患者,采用超声引导下微创乳房肿瘤旋切术,对乳腺肿瘤进行微创旋切,切除乳腺肿瘤进行活检诊断,并评价乳房肿瘤旋切术治疗乳腺良性肿瘤的临床应用价值。结果所有病灶均成功切除。63例86处乳腺肿瘤病灶中,乳腺癌6例(7处),做乳腺癌进一步治疗;乳腺腺病16例(19处);乳腺腺病伴纤维腺瘤形成18例(19处);乳腺纤维腺瘤23例(41处)。结论肿瘤微创旋切系统可明确诊断可疑病灶,完整切除乳腺良性病灶,操作简易,创伤小,安全,美容效果好。若乳腺肿瘤为恶性,可根据微创旋切术切除组织标本,确定癌组织生物学特性,并据乳腺肿瘤组织病理结果,进一步进行治疗。
Objective To investigate the atherectomy in the biopsy diagnosis and treatment of breast tumor. Methods 63 patients with breast tumor (86 lesions) in our hospital from January 2008 to January 2013 were treated with ultrasound-guided minimal invasive atherectomy of breast tumor. The breast tumor tissue was taken for biopsy diagnosis, and the clinical value of atherectomy in the treatment of breast tumor was evaluated. Results All lesions were removed successfully. In all 63 patients (86 lesions), there were 6 cases (7 lesions) of breast cancer, 16 cases (19 lesions) of adenosis of breast, 18 cases (19 lesions) of adenosis with fibroadenoma forming, and 23 (41 lesions) of breast fibroadenoma. Conclusions Tumor minimally invasive biopsy system can confirm the diagnosis of suspicious lesions, and completely resect benign breast lesions. It is easy to operate and safe, with less invasive and good cosmetic results. If breast tumor is malignant tissue, the tissue specimens of minimally invasi

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乳腺肿瘤新生血管在肿瘤生长、肿瘤转移及肿瘤治疗中起重要作用。超声造影(contrast-enhanced ultrasound,CEUS)能够通过显示乳腺肿瘤中血管生成情况来提高乳腺良恶性肿块的诊断准确性。本文主要对乳腺良恶性肿瘤超声造影特征的研究进展进行综述。
Breast tumor neovascularization plays an important role in tumor growth , tumor metastasis and tumor therapy. CEUS (contrast-enhanced ultrasound, CEUS) can improve the diagnostic accuracy of benign and malignant breast tumors by displaying neovascularization in breast tumors. The Development of characteristics of benign and malignant breast tumors on contrast-enhanced ultrasound wil be reviewed in this article.

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目的探讨超声弹性成像联合声触诊组织成像量化技术(VTQ)诊断乳腺良恶性肿瘤的准确性。方法选择118例乳腺肿瘤患者,术前行VTQ及超声弹性成像检查,测量乳腺肿瘤内部的VTQ值,并对肿瘤硬度进行评分,以术后病理结果为金标准,计算超声弹性成像联合声触诊组织成像量化技术诊断乳腺肿瘤良恶性的准确性。结果超声弹性成像、VTQ技术单独和联合使用对鉴别诊断乳腺肿瘤良恶性与病理结果比较,差异均有统计学意义(P0.05)。ROC曲线显示,以硬度评分4分为临界值,超声弹性成像诊断乳腺肿瘤良恶性的灵敏性为92%,特异性为91%。以肿瘤内部VTQ值3.91m/s为临界值,VTQ技术诊断乳腺肿瘤良恶性的灵敏性为85%,特异性为97%。超声弹性成像联合VTQ技术诊断乳腺肿瘤良恶性的灵敏性为93%,特异性为95%。结论超声弹性成像联合VTQ技术能提高诊断良恶性乳腺肿瘤的准确性。
Objective To investigate the diagnostic accuracy of breast tumors by the virtual touch tissue quantification technique combined with ultrasound elasticity imaging.Methods 107 cases of breast tumors were enrolled in this study,the virtual touch tissue quantification technique and ultrasound elasticity ima-ging technique were performed at preoperative.The shear wave velocity (SWV)was measured by the VTQ in tumor center,and the grade of breast tumor hardness was valued by elasticity imaging technique.Using postoperative pathological results as the golden standard,the diagnostic accuracy of breast tumors by the virtual touch tissue quantification and ultrasound elasticity imaging were calculated.Results There was statistically significant in differential diagnosis of benign and malignant breast tumors by ultrasound elas-ticity imaging (P <0.05),and the ROC curve showed that with the hardness grade 4 as the critical value, the sensitivity was 92% and the specificity was 91% to diagnosis the

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提取乳腺肿瘤超声图像的肿瘤区域,计算乳腺肿瘤图像的纹理特征参数,研究纹理特征与肿瘤良恶性的关系。基于综合空间灰度共生矩阵计算11个乳腺肿瘤超声图像的纹理特征参数,然后分别利用模糊C均值和K-medoid聚类算法对乳腺肿瘤进行良恶性判别,同时,通过重复实验找到判别肿瘤良恶性的最佳特征参数组合。实验结果表明相关性、和方差、相关信息度量1和相关信息度量2四个特征参数组合的判别结果最好,达到了72.64%。因此,纹理特征在一定程度上能够反映良恶性乳腺肿瘤的区别,其对于鉴别乳腺肿瘤的良恶性是有效的。
To extract the tumor area of the breast tumors in ultrasonography, upon which calculate the textural features and study the relationship between textural features and pathological nature of the tumors. Eleven textural features are calculated based on the in-tegrated spatial gray level co-occurrence matrix, and the Fuzzy C-means and K-medoid algorithms are applied to differentiate the be-nign and the malignant breast tumors respectively. Meanwhile, the best combination of textural features is determined through repeat-ed experiment. It shows that the combination of feature correlation, sum variance, information measure of correlation 1 and informa-tion measure of correlation 2 can bring the best differentiation result with accuracy of 72.64%. Therefore the textural features can re-flect the difference of benign and malignant breast tumors to some extent, and which is effective in differentiating the benign and ma-lignant breast tumors.

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目的:对乳腺叶状肿瘤的发病机制、病理学特征以及诊断预后进行分析与探讨。方法选取10例乳腺叶状肿瘤患者,通过免疫组化SP法与HE染色进行乳腺叶状肿瘤病理诊断分析。结果研究结果表明,一般肿瘤都发生在单侧,主要位于乳腺外上象限。病理诊断为良性上皮与肿瘤性间质细胞成分,其中肿瘤间质细胞S-100(-),80%action、、vinentin(+)、CD34、desmin阳性表达。结论病理诊断分析表明,乳腺叶状肿瘤是一种比较罕见的病情,而且表现出多样化病理形态,所以对乳腺叶状肿瘤进行全面认识,对该疾病的正确诊断与治疗具有非常重要的意义。
Objective The pathogenesis of breast tumor, pathological features and prognosis diagnosis were analyzed and discussed.Methods Select 10 breast cancer patients, by HE staining with immunohistochemical SP method breast tumor pathological diagnosis analysis.Results The results show that the average tumor occurred in unilateral, quadrant goes up outside, mainly in mammary gland. Pathological diagnosis of composition and benign epithelial tumor stroma cells, including tumor stroma cells S-100(-), action, and 80% vinentin (+), CD34, desmin positive expression.Conclusion Pathological diagnosis analysis indicate that breast cancer is a rare condition, pathological morphology and show the diversification, so to a comprehensive understanding of leaf breast cancer, the correct diagnosis and treatment of the disease has very important significance.

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目的探讨乳腺叶状肿瘤的病理特征,诊断、鉴别诊断,文献复习以及治疗的关系。方法对经手术和病理诊断的2例乳腺叶状肿瘤的临床病理资料进行回顾性分析。结果肿瘤的复发率随病理组织学等级递增而升高,随手术范围增大而下降,并与乳腺纤维腺瘤,乳腺纤维肉瘤,乳腺肌上皮瘤,巨大纤维腺瘤等鉴别。结论建议不管叶状肿瘤病理组织学分类如何,仍把它看是低度恶性或恶性病变处理。
Objective To explore the pathological features, diagnosis, differential diagnosis and treatment of cystosarcoma phylloides. Methods Retrospective analysis of the pathological data of 2 cases with cystosarcoma phylloides who have been treated with surgery. Results The recurrence rate of cancer with histopathological grade increment rise, decline with the surgery increases the scope. This disease must be differential with fibroadenoma of the breast, fibrosarcoma of breast, myoepithelioma of the breast, huge fibroadenoma and other identification. Conclusion Recommended that regardless of the cystosarcoma phylloides pathological classification, it must be treated as a low malignant or malignant lesions.

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探讨纹理特征在超声乳腺肿瘤诊断中的价值。提取超声图像中乳腺肿瘤的纹理度量,得到由均值、标准差、平滑度、三阶矩、一致性和熵组成的特征矢量,最后用反向传播人工神经网络(BP)对96幅乳腺肿瘤的良恶性进行分类识别。BP神经网络对良、恶性肿瘤的正确识别率分别为88.4%和78.6%。基于乳腺肿瘤超声图像的纹理特征建立的神经网络系统对肿瘤的良恶性具有较好的识别能力。
To evaluate the value of texture features in diagnosing breast tumor of ultrasonic image.Texture measurement were ob-tained from breast tumor in ultrasonic image.Six parameter consisting of mean,standard deviation,smoothness,third moment,con-formity and entropy resulted in the character vector.The back -propagation(BP)neural network was used to classify tumors into be-nign and malignant.BP neural network yielded the following results:88.4% and 78.6% respectively.The proposed system based on texture features performs well in the ultrasonic classification of breast tumors as benign or malignant.

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乳腺癌是威胁妇女健康和生命的头号恶性肿瘤,但其发生发展的机制及诊疗仍然没有长足的进展。蛋白酪氨酸磷酸酶11(PTPN11)是一个易于突变的基因,参与乳腺肿瘤的发生,但目前关于 PTPN11调控乳腺癌的体内证据仍然缺乏。为了明确PTPN11 在体内对乳腺癌发生发展的调控作用,利用大鼠乳腺肿瘤的动物模型,用 PTPN11 蛋白酶活性抑制剂 Phps1处理,然后观察乳腺肿瘤发生的情况。结果发现Phps1处理后可延长DMBA诱导的大鼠乳腺肿瘤的潜伏期,延迟肿瘤的发生,并显著降低了DMBA诱发肿瘤的比率(P<0.05),但对肿瘤生长的抑制作用不显著。证明了PTPN11参与调控体内乳腺肿瘤的发生,为理解和诊治乳腺癌提供了一个可能新的靶点。
Breast cancer is one of the major disease threats to women''s health and life,and has become the top one in women''s malignant tumor list.The human gene ptpn1 1 (coded protein tyrosine phosphatase )is easy to be mutated,and involved in the occurrence of breast tumor.But the evidences of the regulation in vivo of PTPN1 1 on breast cancer are still lacking.To investigate the role of PTPN1 1 in the development of breast cancer invivo,we treated the rat with DMBA-induced breast tumor by the activity inhibitor (Phps1) of PTPN1 1 and observed the tumor in rats.We found that Phps1 delayed the occurrence of DMBA-induced breast tumor in rats.The proportion of DMBA-induced tumor was significantly reduced (P<0.05).The number of tumors in Phps1-treated rats had a reduction of 7%-10%.But the tumor growth was not blocked.These results are preliminary evidence that PTPN1 1 involved in regulating the occurrence of breast tumor invivo.
目的探讨乳腺肿瘤外科信息平台建设的方法。方法从目标定位、总体框架、功能对乳腺肿瘤外科信息平台进行构建。结果信息平台的建设可为乳腺肿瘤病人提供全方位的照护。结论信息平台的建设可进一步提高乳腺肿瘤病人的护理质量。
Objective To explore the methods of breast tumor surgery information platform construction.Method To construct the information platform from target location,overall framework,function etc.Result The building of information platform provided a full range of care for breast cancer patients.Conclusion The construction of information platform can further improve the quality of nursing in breast cancer patients.

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目的统计北京市大兴区人民医院近10年手术切除的乳腺肿瘤2 374例,分析其组织学特点,为地区妇女保健工作的开展提供科学依据。方法回顾整理2003-2012年手术切除乳腺肿瘤的病理资料,严格按照世界卫生组织乳腺肿瘤标准(2012)进行病理诊断及分类。结果 2 374例乳腺肿瘤患者中良性肿瘤1 900例(80.0%),恶性肿瘤474例(20.0%),良、恶性之比4.01∶1,好发部位均以左侧多见,良性肿瘤可同时发生在双侧乳腺,而恶性肿瘤同时发生在双乳的情况在本组研究中未见。乳腺良性肿瘤中以乳腺纤维腺瘤(70.5%)多见,乳腺良性肿瘤平均发病年龄约为31.6岁;恶性肿瘤中以浸润性癌(非特殊型)为多见,占81.3%,乳腺恶性肿瘤平均发病年龄约为52.3岁。年轻妇女乳腺癌(35岁或35岁以下)占5.91%。结论研究结果显示乳腺肿瘤以良性肿瘤为主,好发于左侧乳腺,乳腺良性肿瘤以纤维腺瘤最为常见,恶性肿瘤以浸润性癌(非特殊型)最常见。乳腺良性肿瘤发病年龄高峰在21-30岁,乳腺恶性发病年龄高峰在41-50岁。年轻妇女(35岁及以下)乳腺恶性肿瘤患病率在国内处于较低水平。
Objective To summarize the pathological characteristics of specimens of breast tumors in 2374 cases in this hospital during re-cent 10 years,and to analyze the characteristic histological features in order to provide a scientific basis for implementation of womenˊs health care in this region. Methods The data of surgical removal specimens of breast tumor during 2003 to 2012 in this hospital were retrospectively reviewed and analyzed,according to the criteria of WHO for breast tumor classification(2012)for pathological diagnosis and classification. Results A-mong these 2 374 cases of surgical removal specimens of breast tumors,there were 1 900 cases of benign tumors( 80. 0%),474 cases of malig-nant tumors(20. 0%). The ratio of benign to malignant tumors was 4. 01: 1,The most common position was in left side of breast,the benign tumors usually occurred in both sides,and malignant tumors might occasionally occurred in both sides in this study. Among benign tumors,fibro-adenoma

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