E读

双语推荐：妇癌

目的：探讨电子阴道镜在诊断筛查宫颈癌中的临床应用价值。方法通过对上栗县9600位女性进行妇科疾病的筛查，使用妇检、白带常规、醋酸或碘染色试验、阴道镜检查、病理活检、B超等检查手段，比较分析阴道镜检查结果的准确率以及临床应用价值。结果电子阴道镜实查278例中，查出宫颈上皮内瘤样病变14例（5.0%），宫颈癌5例（1.2%），尖锐湿疣1例（0.4%）；病理活检实查46例，查出宫颈上皮内瘤样病变14例（30.4%）（包括CINⅠ7例，CINⅡ2例，CINⅢ5例），宫颈癌1例（2.2%）（浸润癌1例），尖锐湿疣1例（2.2%）。病理活检在宫颈上皮内瘤样病变、宫颈癌、尖锐湿疣等方面的检出率高于阴道镜检出率（P〈0.05）。结论电子阴道镜作为筛查宫颈癌的重要手段之一，其作用不可忽视，具有较高的临床价值。

Objective To investigate the application value of colposcopy in screening of cervical cancer. Methods 9600 women with gynecological diseases in Shangli County were screened,and gynecological examination,leucorrhea routine, acetic acid or iodine staining test,colposcopy,biopsy,B ultrasound inspection method were used to analyze accurate rate of colposcopy results and its application valute. Results 278 patients were detected with colposcopy examination,in-cluding 14 cases (5.0%) with cervical intraepithelial neoplasia,5 cases (1.2%) with cervical carcinoma,and 1 case (0.4%) with condyloma acuminatum.46 patients were detected with biopsy truth,including 14 cases (30.4%) of cervical intraep-ithelial neoplasia (including 7 cases of CINⅠ,2 cases of CINII,5 cases of CINⅢ),1 case (2.2%) with cervical cancer (1 case with infiltrating carcinoma),1 case (2.2%) with condyloma acuminatum.Detection rate of pathological biopsy in cervical intraepithelial neoplasia,cervical cancer,condylo

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目的探讨新疆喀什地区伽师县克孜勒博依乡维吾尔族妇女人群 HPV （Human papilloma virus ，人乳头瘤病毒）感染情况及 HPV感染与不同程度宫颈病变的关系，为制定新疆农村妇女宫颈癌防治对策和措施提供科学依据。方法于2011年6月15日-7月15日在伽师县克孜勒博依乡选择30～60岁的1300例维吾尔族妇女为主要研究对象。所有研究对象接受问卷调查、妇检、HPV-DNA检测（HC-Ⅱ）、液基细胞学检查，对于 HPV-DNA检测（HC-Ⅱ）与液基细胞学检查任意一项阳性者行阴道镜下宫颈活组织检查。结果（1）喀什地区伽师县克孜勒博依乡妇女 H PV总阳性率为10．31％。宫颈液基细胞异常率为2．77％。（2）不同宫颈病变脱落细胞中 H PV DNA 负荷量中位数最高为宫颈癌，最低为慢性宫颈炎，慢性宫颈炎组与CIN组及宫颈癌组比较，差异有统计学意义（P ＜0．05）；CIN各组和宫颈癌组之间比较差异无统计学意义（P ＞0．05）。（3）HPV感染组中，细胞学阳性率分别为：ASCUS 42．11％、ASC-H 50％、LSIL 66．7％、HSIL 66．7％、浸润癌100％，与 HPV非感染组阳性率比较差异有统计学意义（P ＜0．05）；随着宫颈病变程度的加重，HPV阳性率也逐渐升高，且在各种宫颈细胞学病例中HPV感染的阳性率差异有统计学意义（P＜0．05）。结论 HPV感染率与宫颈病变严重程度有关；宫颈细胞学异常与H PV感染有关；高病毒负荷量可能比患宫颈癌及宫颈上皮内瘤变的风险更大，但是不能用来预测宫颈病变的严重程度。

Objective By investigating the infection of human papillomavirus (HPV ) and distribution of HPV subtypes in population ,and the relation between HPV infections with squamous intraepithelial lesion in the Kizilbuy village in Kashgar Xinjiang ,provides a scientific basis for the development of cervical canc-er prevention strategies and measures .Methods A population based cervical cancer screening was done from June15 to July 15 ,2011 ,among 1 ,300 women in Kizilbuy township of Payzawat ,Kashgar ,Xinjiang ranging in age from 30 to 60 .And all of the objectives were carried through questionnaire performing , HPV-DNA testing ,liquid-based Cytology the patient who had positive for the HPV-DNA testing and liq-uid-based cytology was put up colposcopic biopsy .Results (1) 134(10 .31% ) women in all were HPVpositive ,diagnosis ≥ASCUS by liquid-based cytology was 2 .77% (36/1 ,300) .(2) In different cervical le-sions ,the highest median load shedding of HPV is cervical cancer ,and the lowest is