目的：探讨医用面膜辅助异维 A酸治疗中度痤疮的临床疗效。方法：将入选患者32例，随机分为治疗组和对照组各16例。治疗组使用医用面膜和口服异维 A酸治疗，对照组单用口服异维 A 酸治疗，10周疗程评价两组临床疗效。结果：治疗组总有效率为100％；对照组总有效率为68．75％，两组疗效差异比较有统计学意义（P＜0．05）。结论：临床使用医用面膜辅助口服异维 A 酸比单用口服异维 A酸治疗中度痤疮更加有效且副作用少。

Objective :To explore the clinical efficacy of medical mask assisted with oral isotretinoin for treatment of moderate acne . Methods :A total of 32 patients were randomly divided into two groups ,the treatment group and the control group .Each group contains 16 cases .The treatment group was treated with medical mask and oral isotretinoin .The control group was treated only with oral isotretinoin . Ten weeks of treatment ,and evaluate the clinical efficacy of two groups .Results :The total effective rate of treatment group was 100% ,con-trol group was 68 .75% .There was statistically significant difference between the two groups (P< 0 .05) .Conclusion :Clinical use medical mask assisted with oral isotretinoin was more effective than single oral isotretinoin treatment of moderate acne .And the adverse effects are minimal .

目的探讨异维A酸联合复方多黏菌素B软膏治疗中重度痤疮的临床效果。方法选择中重度痤疮患者60例为研究对象,随机分为研究组和对照组各30例,研究组联合异维A酸和复方多黏菌素B软膏治疗,对照组单用异维A酸治疗,比较两组患者的临床治疗效果。结果研究组总效率显著高于对照组(P0.01),平均起效时间短于对照组(P0.01)。结论异维A酸联合复方多粘菌素B软膏治疗中重度痤疮具有较好的临床疗效,并且起效快,不良反应少,值得临床推广。

Objective To discuss the clinical efficacy of acutane combined with compound much slime molds element B ointment for moderate to severe acne. Methods Selected 60 cases with moderate to severe acne were divided into study group and control group.Study group was treated by acutane combined with compound much slime molds element B ointment, and control group was treated by acutane.Clinical efficacy of two groups was compared. Results Total efficacy of study group was higher than that of control group(P < 0.01).And onset time was shorter than that of control group(P<0.01). Conclusion Acutane combined with compound much slime molds element B ointment for moderate to severe acne shows better clinical efficacy, less complications, and worthy of spreading in clinical practice.

目的 观察夫西地酸乳膏联合异维A酸胶囊治疗重度痤疮的临床疗效及安全性.方法 选取2011年7月至2013年6月在我科确诊为重度痤疮的患者89例,随机分为观察组42例和对照组47例,观察组采取外用夫西地酸乳膏配合内服异维A酸胶囊,对照组采取内服阿奇霉素软胶囊和异维A酸胶囊,治疗8周后,观察患者的皮损变化情况和用药副作用的发生情况.结果 观察组治疗有效率与对照组比较,经x 2检验,x 2=0.036,P=0.850,差异无统计学意义;观察组在治疗过程中出现不良反应症状的例数与对照组比较,经x2检验,x2=4.732,P=0.03,差异有统计学意义;观察组有1例肝转氨酶升高、占2.4％,对照组有4例转氨酶升高、占8.5％,经x2检验,x2=1.572,P=0.21,差异无统计学意义.结论 外用夫西地酸乳膏配合内服异维A酸胶囊与内服阿奇霉素软胶囊和异维A酸胶囊具有同样的治疗效果,但药物副作用更少,更安全,患者耐受治疗的比例也更高,因此,推荐夫西地酸乳膏配合内服异维A酸胶丸治疗严重痤疮.

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评价强脉冲光治疗酒渣鼻的疗效。方法:治疗组采用强脉冲光照射,每3周1次,4次为1疗程;对照组口服异维A酸10 mg,日2次,连续12周。结果:治疗组总有效率为89.74%,对照组为71.05%,差异有统计学意义(P0.05)。结论:强脉冲光治疗酒渣鼻疗效优于异维A酸。

To assess the efficacy of intense pulsed light (IPL) in the treatment of rosacea. Methods: The treatment group were treated with IPL, once every 3 weeks for four times. The control group were treated with isotretinoin 10 mg, twice a day for 12 weeks. Results: The total effective rates of the IPL group and isotretinoin group were 89.74% and 71.05%, with a significant difference between the two groups (P<0.05). Conclusion: The clinical efficacy of IPL is more effective than isotretinoin in the treatment of rosacea.

目的：观察口服异维A酸联合光动力疗法治疗尖锐湿疣的临床疗效和对血清白细胞介素（Interleukin，IL）－2水平的影响。方法将48例尖锐湿疣患者随机分为2组， A组行单纯光动力治疗；B组口服异维A酸胶囊联合光动力治疗，所有患者每2周随访1次，记录皮损改善情况及不良反应，并测定所有患者治疗后血清IL－2的水平。？结果 B组治疗有效率明显高于A组（P＜0．05），而复发率小于A组（P＜0．05），治疗后B组血清IL－2的水平显著高于A组（t＝2．329，P＜0．05）。结论口服异维A酸具有一定细胞免疫调节作用，其联合光动力疗法对尖锐湿疣具有较好的临床疗效。

Objective To observe therapeutic ef ect and influence on serum level of interleukin-2 of oral isotretinoin with ALA-PDT therapy in thetreatment of condyloma accuminatum. Methods Total y 48 cases of condyloma accuminatum patients diagnosed in outpatient were randomly divided into 2 groups.Group A:24 cases,only ALA-PDT treatment.Group B:24 cases, ALA-PDT treatment with oral isotretinoin 10 mg,3 times a day,and turning to 10 mg per day til the lesion disappearing clearly,stopping after 1 month.Al groups have observation the other week,recorded lesion condition and adverse ef ect.Al subjects were measured for the serum levels of interleukin-2 (IL-2)using double antibody sandwich enzyme-linked immunosorbent assay (ELISA)method after treatment.Fol ow up 6 months.Results There was significant dif erence between Group A and B in therapeutic ef ect and recurrence rate(P<0.05 ).The serum levelofIL-2inGroupBwassignificantlyhigherthanGroupAaftertreatment(P<0.05).ConclusionThetherapiesofo