目的系统评价红景天注射液治疗心绞痛的疗效及安全性。方法计算机检索Pub Med、Embase、Cochrane Library、CNKI、万方及VIP数据库中所有红景天注射液治疗心绞痛的疗效及安全性的随机对照研究,按照纳入和排除标准筛选文献、提取资料,并依据Cochrane Handbook 5.0.1的质量评价标准评价纳入研究的方法学质量。主要结果包括疾病疗效、心绞痛疗效、心电图疗效、中医证候总积分及不良反应。根据异质性检验结果选择固定效应模型或随机效应模型进行Meta分析。结果共纳入12个随机对照试验,合计1 442例患者。Meta分析主要结果显示:1红景天注射液+西医常规治疗组与西医常规治疗组比较,疾病疗效(RR=1.27,95%CI(1.09,1.48))、心绞痛疗效(RR=1.25,95%CI(1.14,1.38))及心电图疗效(RR=1.21,95%CI(1.10,1.34))差异均有统计学意义。2红景天注射液组与复方丹参注射液组比较,疾病疗效(RR=1.25,95%CI(1.04,1.50))、心电图疗效(RR=1.28,95%CI(1.09,1.50))及中医证候疗效(RR=1.09,95%CI(1.00,1.18))差异均有统计学意义,然而心绞痛疗效差异无统计学意义(RR=1.10,95%CI(0.92,1.32));与血塞通注射液组比较,心绞痛疗效(RR=1.08,95%CI(0.84,1.39))及心电图疗效(RR=1.13,95%CI(0.87,1.47))差异均无
Objective It is to systematically assess the clinical effectiveness and safety of rhadiola injection for angina pec-toris.Methods The databases such as PubMed,Embase,Cochrane Library,CNKI,WanFang and VIP were searched to collect all randomized control trials(RCTs)about the clinical effectiveness and safety of rhadiola injection for angina pectoris.Litera-tures were screened according to the inclusive and exclusive criteria,the data were extracted,the methodological quality of the included studies was assessed in line with Cochrane Handbook 5.0.1.The primary outcome measure including therapeutic effect, angina treatment effect, electrocardiogram ( ECG) curative effect, general integral of traditional Chinese medicine (TCM) symptoms and adverse drug reaction.The meta-analysis was performed with the fixed -effect model or random-effect model according to heterogeneity.Results Twelve RCTs with 1442 patients were included.The outcomes of meta-analyses showed that, ①rhadiola injec