Objective To investigate the method of nursing care of pain in patients with tumors. Methods Randomly selected in our hospital from 2011 January to 2011 October were treated 70 patients with tumor, take a comparison between before and after the nursing intervention measures. Results 70 patients were compared before and after implementation of pain nursing in 450 cases, nursing, patients with mild pain in 65 cases, 165 had moderate pain, severe pain in 220 cases;nursing intervention measures, no pain in 90 cases, slight pain in 231 cases, 109 had moderate pain, severe pain in 20 cases. Conclusion Reasonable analgesic therapy combined with nursing intervention, relieve pain, relieve the pain of patients.