探讨血清胱抑素 c 测定在慢性肾病早期诊断中的应用价值及干预措施。方法检测200例慢性肾病患者和50例健康体检者血清胱抑素 c、血肌酐（SCr）、尿素氮（BUN）水平，计算肾小球滤过率（eGFR）。结果3项观察指标均与血清胱抑素 c 相关，但血清胱抑素 c 与 eGFR 的相关程度最密切，在慢性肾病早期胱抑素 c 改变较其他指标更敏感。结论血清胱抑素 c 在慢性肾病各期均有较高的检出率，能敏感提示早期肾损害。

Objective To discuss the value and intervention mesures of using serum cystatin C in the early diagnosis of chronic kidney disease. Methods There were 200 cases of chronic kidney disease patients and 50 healthy subjects, accroding to serum cystatin C, serumcreatinine(Scr), blood urea nitrogen (BUN) levels, caculating glomerular filtration rate (eGFR). Results 3 observation indexes were relavent to serum cystatin C, but serum cystatin C closely related to eGFR , moreover in the early stage of chronic kidney disease cystatin C was more sensitive than other indicators. Conclusion Serum cystatin C is a sensitive mark of early renal damage, and in the chronic kidney disease the detection rate was high.

研究血清胱抑素C在早期肾功能损害诊断过程中的临床作用。方法:回顾2010年12月-2013年1月早期肾功能损害患者81例,将其作为试验组,选择同期81例身体健康者作为对照组,对比两组研究对象的尿素浓度、血清肌酐(Scr)、血清胱抑素C浓度(Cyst C)。结果:与对照组相比,试验组患者的尿素浓度、血清肌酐、血清胱抑素C浓度更高,差异有统计学意义(P0.05)。结论:对于早期肾功能损害患者,将其血清胱抑素C应用在诊断过程中,能够将其肾小球过滤功能与肾功能变化反映出来,提高早期肾功能疾病诊断率,血清胱抑素C在早期肾功能损害诊断中的诊断价值值得肯定,可将血清胱抑素C作为早期肾功能损害的重要依据。

Objective:To study the clinical effect of serum cystatin C in the diagnosis of early renal damage.Method:To retrospective 81 cases with the early impairment of renal function from December 2010 to January 2013,which were as the experimental group,to select the same period in 81 cases of healthy persons as control group,the concentration of urea,serum creatinine compared two groups of subjects(Scr),serum cystatin C(Cyst C).Result:The concentration of urea,serum creatinine,serum cystatin C concentration of the experimental group were higher compared with control group,the differences between the two groups of data was significant(P<0.05).Conclusion:For the patients with early renal damage,the application of cystatin C in the diagnostic process,to the glomerular filtration function and renal function changes reflected in early renal diseases,it can improve the diagnosis rate.

探讨血清胱抑素C对妊娠晚期早期肾损害的诊断价值。方法:对1400例住院妊娠晚期妇女和产妇进行血清胱抑素C、尿素、肌酐三项指标监测统计分析。结果:血清胱抑素C在妊娠晚期和产妇中含量为(0.94±0.26)mg/L,明显高于健康体检妇女(0.68±0.13)mg/L,差异有统计学意义(P0.001);尿素和肌酐低于对照组。结论:血清胱抑素C是反映孕妇早期肾损害的一项敏感而可靠的指标。

Objective:To explore the diagnostic value of studying Cystatin C level in pregnant women with early renal disfunction during the third trimester. Method:Comparing and analyzing the data from monitoring of the three indexes(Cys-C,serum creatinine and blood urea)in 1400 cases.Result:The level of serum Cys-C was significantly higher in pregnant group than in non-pregnant group(P<0.001).The level of serum creatinine and blood urea were lower in pregnant group. Conclusion:The level of Cys-C is a sensitive and reliable index of early renal disfunction on pregnant women during the third trimester.

探讨尿酸、胱抑素C(Cystatin C)与急性脑梗死的关系。方法:选取我院2012年1月-2013年12月收治的268例急性脑梗死患者为病例组,选取同期来我院体检的242名健康者为对照组,检验其血清中尿酸、胱抑素C、血脂等指标。结果:病例组患者的尿酸及Cystatin C水平明显高于对照组,差异有统计学意义(0.05),Logistic回归分析显示尿酸(OR=0.538,=0.027)、胱抑素C(OR=17.671,=0.001),均是急性脑梗死的危险因素,经控制其他因素后,血清胱抑素C与急性脑梗死仍密切相关(OR=19.987,=0.001)。结论:血清尿酸及胱抑素C与急性脑梗死的发生密切相关,在急性脑梗死发生发展起到一定的作用,血清胱抑素C可能是急性脑梗死独立危险因素。

Objective: To study of the relationship between Serum uric acid and Cys-C level in patients with acute cerebral infarction. Metheds:Selected from January 2012 to December 2013 treated 268 cases of acute cerebral infarction patients (case group),and at the same time to the hospital physical examination of 242 healthy subjects (control group),test the serum uric acid,Cystatin C (Cys-C),blood lipids and other indicators. Results:The patient''s level of uric acid and Cystatin C cases group was obviously higher than that of control group, the difference was statistically significant( <0.05),Logistic regression analysis showed that uric acid (OR=0.538,=0.538) in inhibition C (OR=17.671,=17.671),is a risk factor for acute cerebral infarction,after controlling other factors, serum Cys C are closely associated with acute cerebral infarction is still (OR=19.987,=19.987). Conclusion:Serum uric acid and Cys C is closely related to the occurrence of acute cerebral infarction, occurrence a

目的探讨非症状性癫痫患者血清胱抑素C水平变化及其临床意义。方法选取我院2011年1月—2014年3月收治的非症状性癫痫患者37例作为病例组,选取同期在我院体检健康者60例作为对照组。检测两组受检者血清胱抑素C水平,采用STESS量表评价病例组患者癫痫严重程度。结果病例组血清胱抑素C水平为（1.43±0.29）mg/L,高于对照组的（0.87±0.21）mg/L（t=11.005,P〈0.001）;亚组分析发现,不同性别、年龄段非症状性癫痫患者血清胱抑素C水平比较,差异均无统计学意义（P〉0.05）;不同STESS量表评分非症状性癫痫患者血清胱抑素C水平比较,差异有统计学意义（P〈0.05）。结论非症状性癫痫患者血清胱抑素C水平升高,并与癫痫严重程度密切相关,对非症状性癫痫的诊治有一定参考意义。

Objective To investigate changes and significance of serum Cystatin C levels in patients with non - symp-tomatic epilepsy. Methods From January 2011 to March 2014,a total of 37 patients with non - symptomatic epilepsy were cho-sen as case group in our hospital,60 healthy cases were chosen as control group at the same time. Serum Cystatin C levels of the two groups were detected,and STESS scale was used to evaluate the severity of epilepsy. Results The serum Cystatin C levels of case group was(1. 43 ± 0. 29)mg/ L,was higher than that of control of(0. 87 ± 0. 21)mg/ L(t = 11. 005,P ﹤ 0. 001);sub - group analysis showed that,there was no significant differences of serum Cystatin C levels in non - symptomatic patients with different gender,at different ages(P ﹥ 0. 05),but there was in non - symptomatic patients with different scores of STESS scale. Conclusion Patients with non - symptomatic epilepsy have a higher serum cystatin C level,which is correlated with the severity of