辅酶Q10是线粒体电子传递链中的一种重要辅酶,也是存在于线粒体中的一种重要脂溶性抗氧化剂。辅酶Q10在医学上的应用十分广泛,主要体现在心血管疾病、高血压、神经系统疾病方面。近些年来研究发现辅酶Q10在高原医学方面也有很大的应用前景,现对其进行综合阐述。

Coenzyme Q10 is not only an important coenzyme in the mitochondrial electron transport chain ,but also one of the important fat-soluble antioxidants existing in the mitochondria .It has been widely used in medicine , especially in cardiovascular diseases ,hypertension ,nervous system diseases ,and etc .Studies have found that coen-zyme Q10 may also have a great application prospect in high altitude medicine ,and this review will give some proof about that .

目的：观察重组人组织型纤溶酶原激酶衍生物（rPa）联合辅酶Q10治疗急性st段抬高型心肌梗死的疗效及安全性。方法选80例符合溶栓治疗指征的急性st段抬高型心肌梗死患者随机分为常规溶栓治疗组和辅酶Q10组，每组各40例；辅酶 Q10组于溶栓治疗同时给予辅酶 Q10治疗。分别于治疗前、治疗后24 h检测2组患者血浆肌钙蛋白 i(ctni)、肌酸激酶同工酶(cK-MB)以及超氧化物歧化酶(sod)活力；所有入选患者2周时行心脏彩超检查，采用 simpson 法测定和计算左室舒张末期内径、左室收缩末期内径、左室射血分数；观察2组治疗后2 周内心血管不良事件发生率。结果（1）辅酶 Q10组血管再通率高于常规溶栓组（65.7%：62.8%），但两组比较差异无统计学意义（P＞0.05）。（2）与溶栓治疗前比较，两组治疗后血浆 cK-MB，ctni ，sod 较治疗前明显升高，且 sod 活性升高低于 cK-MB，ctni升高幅度（P<0.05），辅酶 Q10组治疗后血浆 cK-MB ，ctni 升高幅度明显低于常规溶栓组，sod 活性明显高于常规溶栓组（P<0.05）。（3）常规溶栓组左室舒张末期内径、左室收缩末期内径均高于辅酶 Q10钠组，左室射血分数低于辅酶 Q10钠组（分别为56.01±3.48 mm 比50.69±2.99 mm，P<0.05；47.89±4.76 mm 比41.

Objective to observe the effects of recombinant human tissue type plasminogen kinase derivatives (rPa) effect and safety of combined with coenzyme Q10 in the treatment of acute st segment elevation myocardial infarction. Methods 80 patients with acute st syndrome refers to comply with thrombolytic therapy in patients with the segment elevation myocardial infarction were randomly divided into conventional thrombolytic therapy group and coenzyme Q10 group, 40 cases in each group; coenzyme Q10 group in the thrombolytic therapy at the same time give coenzyme Q10 therapy. respectively in the detection of 24h before and after treatment in 2 groups of patients with cardiac troponin i (ctni), creatine kinase isoenzyme MB (cK-MB) and superoxide dismutase (sod) activity; all patients 2 weeks after cardiac ultrasound examination, determination and calculation of left ventricular end diastolic period inside diameter, left ventricular end systolic diameter, left ventricular ejection fract

目的通过将他汀类药物联合规律运动应用于冠心病患者治疗,观察冠心病患者血清还原型辅酶Q10、高密度脂蛋白-胆固醇(HDL-C)和低密脂蛋度白-胆固醇(LDL-C)含量变化。方法选择30例入住我院冠心病患者随机分为瑞舒伐他汀组和阿托伐他汀组,分别给予相应药物治疗,同时进行院内无氧锻炼1周和家庭锻炼20周,锻炼计划前后分别检测患者的血脂,辅酶Q10和心肺功能;采用相关性分析患者载脂蛋白A1变化与血清还原型辅酶Q10含量之间的关系。结果两组患者的心肺功能均得到改善,同时LDL-C和甘油三酯下降;两组患者HDL-C和载脂蛋白A1均有不同程度提高,但瑞舒伐他汀组提高幅度明显高于阿托伐他汀组;阿托伐他汀组血清还原型辅酶下降明显,差异有统计学意义;相关性分析显示载脂蛋白A1变化与还原型辅酶Q10呈正相关。结论与阿托伐他汀相比,瑞舒伐他汀联合规律运动能够维持冠心病患者还原型辅酶Q10水平同时使HDL-C上升,对冠心病患者具有更加确切有益的疗效。

Objective To investigate the effects of two statins (rosuvastatin and atorvastatin) combined with exercise on the levels of coenzyme Q10, HDL-C and LDL-C in coronary artery disease(CAD) patients. Methods Af-ter randomizing 30 CAD patients into rosuvastatin (n=14) and atorvastatin (n=14) groups, patients performed week-ly in-hospital aerobic exercise and daily home exercise for 20 weeks. The lipids and ubiquinol in serum and exercise capacity were measured, and the correlation analysis was carried out to explore the relationship between apolipopro-tein A1 (ApoA1) and ubiquinol in patients. Results Both statins equally improved exercise capacity and lowered LDL-C and triglyceride levels. Rosuvastatin significantly increased HDL-C and ApoA1 compared to atorvastatin. Atorvastatin significantly decreased ubiquinol level in serum. There was a significant positive correlation between changes in ubiquinol and ApoA1. Conclusion Compared with atorvastatin, rosuvastatin combined with exercise can

目的观察辅酶Q10对高龄慢性心功能不全的疗效及安全性。方法 70例高龄慢性心功能不全的患者随机分为治疗组和对照组,对照组给以常规治疗,治疗组在常规治疗基础上联合辅酶Q10,两组疗程均为2个月,治疗前后观察两组血浆脑钠肽(BNP)的水平、心功能改善程度。结果两组BNP均下降,但治疗组BNP水平下降明显高于对照组,治疗组心功能不全改善较对照组更明显,差异有显著性(P0.05),且治疗组不良反应发生率很低。结论辅酶Q10对高龄慢性心功能不全的有很好的疗效及安全性。

Objective To observe coenzyme Q 10 for the elderly with chronic heart failure efficacy and safety.Methods 70 ca-ses of elderly patients with chronic heart failure were randomly divided into treatment group and control group ,the control group given conventional treatment group and coenzyme Q 10 in the conventional therapy ,treatment lasted two months ,both before and after treat-ment was observed plasma levels of brain natriuretic peptide ( BNP) ,the degree of improvement in heart function.Results There BNP decreased ,but the treatment group decreased significantly higher BNP , cardiac dysfunction improve the treatment group com-pared with the control group more obvious difference was significant (P<0.05),and a low incidence of adverse reactions treatment groups.Conclusion coenzyme Q10 for the elderly with chronic heart failure have a good efficacy and safety .

研究生脉饮对病毒性心肌炎心肌细胞凋亡作用的影响。方法:用柯萨奇B病毒建立感染的心肌细胞模型,在感染后24小时将细胞分为正常对照组、病理模型组、生脉饮组和辅酶Q10组。4组分别在不同时间点观察细胞形态,并采用TUNEL法进行细胞凋亡的检测。结果:在48小时点开始检测,正常对照组无细胞凋亡,生脉饮组及辅酶Q10组均有凋亡,生脉饮组凋亡率低于辅酶Q10组(P0.05),病理模型组随着时间的推移,凋亡率增加,72小时点明显高于48小时点(P0.01),与药物干预组比较差异具有统计学意义(P0.05)。结论:生脉饮能够有效抑制病毒性心肌炎心肌细胞的凋亡,且应该早期干预。

Objective:To study the effect of pulse-activating decoction compound preparation in myocardial apoptosis effect of viral myocarditis.Methods:Using coxsackie B virus established infectious myocardial cell model.In 24 hours after infection,the cells were divided into four groups:the normal control group,the pathological model group,the pulse-activating decoction group and the coenzyme Q10 group.The cellular morphology of four groups of cells were observed at different time points.The apoptosis was detected by TUNEL method.Results:Begin testing at 48 hours,the normal control group had no apoptosis;the pulse-activating decoction group and the coenzyme Q10 group all had apoptosis;the apoptosis rate of the pulse-activating decoction group was lower than that of the coenzyme Q10 group(P<0.05).In the pathological model group,the apoptosis rate was increased as time goes on.72 hours point was obviously higher than 48 hours point(P<0.01).There had statistically significant compared with the drug