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双语推荐：酚酸

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通过测定不同林龄的健康和受害黄檗，在不同生长时期（6月、7月和8月）内雌、雄植株叶片酚酸质量分数的变化，研究了酚酸质量分数与黄檗抗虫性之间的关系。结果表明：性别、树龄、健康状况和生长时期对黄檗叶片内酚酸总量的影响差异均显著（P＜0．05）。健康和受害植株的酚酸总量均表现为7月份＞8月份＞6月份的变化趋势，且不同月份之间差异均极显著（P＜0．01）；雌株的酚酸总量均极显著高于雄株（P＜0．01）；37年生的黄檗总酚酸含量显著高于56年生（P＜0．01），不同树龄的受害植株在所测定的各月份其酚酸总量显著高于健康植株（P＜0．05）；不同树龄之间酚酸总量的差异也极显著。黄檗叶片内共检测出原儿茶酸、绿原酸、咖啡酸、香豆酸、水杨酸、苯甲酸、苯乙酸、阿魏酸和肉桂酸9种酚酸类物质，受害植株的酚酸种类显著高于健康植株。说明性别、树龄、健康状况和发育时期均在不同程度上影响黄檗叶片酚酸质量分数的变化，进而影响黄檗抗虫性强弱。因此，可以根据这一变化规律对抗性较弱的黄檗，采取适当的管理措施维护林木的正常生长。
By measuring the healthy and injured Phellodendron amurense Rupr.at diffreret ages and at different growth stages (June, July and August), the experiment was conducted to determine the female and male phenolic acids content in plant leaves, phenolic acids content of P.amurense Rupr.and the relationship with insect resistance.The content of total phe-nolic acids are significantly different under genders, stands, health condition and growth periods (P August>June, and there is highly significant difference among different months (P<0.01).Female plants of total phenolic acids are significantly higher than male ( P<0.01) .The content of total phenolic acids in 37 years old is significantly higher than that of 56 years old (P<0.01), The content of total phenolic acids in different ages of the injured plants is significantly higher than that in the healthy plants (P<0.05 ).The content of total phenolic acids in different ages is also significant.Nine kinds of phe-nolic acids are detected in

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目的：考查不同因素对丹酚酸B溶液稳定性的影响，为工业化生产应用提供实验依据。方法：通过HPLC检测溶液中丹酚酸B的含量变化。结果：温度和加热时间对丹酚酸B的稳定性有较大的影响，乙醇溶液比水溶液更有利于丹酚酸B的稳定。结论：生产过程中应将浓缩温度控制在60℃以下，时间在4h以内，且溶液中丹酚酸B浓度高有利于稳定。
Objective:To examine the inlfuence of different factors on the stability of salvianolic acid B and to provide an experimental basis for their application in industrial production. Methods:Changes in the content of salvianolic acid B were determined by HPLC. Results:There was a signiifcant effect of temperature and heating time on the stability of salvianolic acid B and salvianolic acid B was more stable in alcohol solution than in water. Conclusion:The temperature for the concentration of salvianolic acid B should be controlled below 60℃and time within 4 hours,and higher concentrations of salvianolic acid B in the alcohol solution are of beneift to its stablity in the production process.

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研究深裂竹根七总酚酸的体外抗菌活性。方法使用正交设计优化深裂竹根七总酚酸提取工艺，选择4种供试菌考察提取物的抑菌活性。结果深裂竹根七总酚酸的最佳工艺为：20倍量80%乙醇浓度，提取3次，每次1.5 h。总酚酸提取物对金黄色葡萄球菌抑制作用强于其他3种菌。结论深裂竹根七总酚酸提取物具有一定抗菌活性。
The total polyphenols extracted from Disporopsis perryi was tested for its in vitro antimicrobial activity in the present study. The total polyphenols extraction process from Disporopsis perryi was optimized by even orthogonal design. The inhibitory effects against four tested strains were evaluated. The optimum extraction technology of total polyphenols was that using 80%ethanol , the amount of which were 20 times of crude drugs , extraction time 1.5 h, 3 times. It presented the best inhibitory effect against Staphylococcus aureus in the four test strain. The extract has antioxidant performance.

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为了研究木质素代谢途径中相关酚酸和类黄酮的测定方法。采用有机试剂萃取和超声破碎细胞的方法对烟草总酚酸和类黄酮进行提取,并通过高效液相色谱（HPLC）对烟草中6种植物酚酸和5种植物类黄酮进行了定量分析。结果显示：有机萃取结合超声破碎细胞的方法能够将酚酸和类黄酮从植物中有效分离;高效液相色谱（HPLC）能够将6种植物酚酸和5种植物类黄酮一次分离;HPLC测定香豆酸、阿魏酸、芥子酸、对甲氧基苯甲酸和肉桂酸的保留时间分别为18.11、20.03、20.51、20.76、22.86、26.23min;HPLC测定杨梅素、槲皮素、根皮素、柑橘素、山奈酚的保留时间分别为9.06、12.01、14.96、15.23、16.12min。通过研究表明,HPLC能够很好的对植物酚酸和类黄酮进行检测,这为研究木质素代谢途径相关酚酸和类黄酮奠定了基础。
The aim was to establish a research method to measure the phenolic and flavonoid which relate to plant lignin biosynthesis. Organic reagent and ultrasonication were used for plant phenolic and flavonoid extract, HPLC was used for the measurement of six plant phenolic and five flavonoids. Tobacco was used as sample to test the HPLC measure method. The result showed that HPLC method for the phenolic and flavonoid relate to plant lignin biosynthesis was efficient which could isolate 6 different phenolics and 5 different flavonoids in one test;organic reagent and ultrasonication were useful to extract plant phenolic and flavonoid;the retention time of p-coumaric, ferulic, caffeic, cinnamic, sinapic and 4-methoxybenzoic acid were 18.11, 20.03, 20.51, 20.76, 22.86 and 26.23 min;the retention time of myricetin, quercetin, phloretin, naringenin and kaempferol were 9.06, 12.01, 14.96, 15.23, 16.12 min. The method made foundation for the research of plant lignin biosynthesis.

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探讨对吗替麦考酚酯进行治疗药物监测的临床必要性。方法:采用HPLC方法测定血浆中麦考酚酸的谷浓度和峰浓度,对2012年10–12月期间83例肾移植患者血浆麦考酚酸浓度进行分析。结果:患者血浆麦考酚酸谷浓度在0.34~3.99μg·mL-1范围内的共46例次,血浆麦考酚酸峰浓度在0.91~12.78μg·mL-1范围内的有37例次。在固定给药剂量下,麦考酚酸血药浓度的个体差异较大。结论:对吗替麦考酚酯进行治疗药物监测具有重要的临床价值。
Objective: To investigate the clinical necessity of therapeutic drug monitoring (TDM) of mycophenolate mofetil. Methods:The peak and trough concentrations of mycophenolic acid in plasma were determined by high performance liquid chromatography (HPLC). Plasma concentrations of mycophenolic acid in 83 cases of renal transplant recipients collected from October to December in 2012 were analyzed. Results: The valley concentrations of mycophenolic acid in 46 patients were within the range from 0.34μg·mL-1 to 3.99μg·mL-1. The peak concentrations of mycophenolic acid in 37 cases were within the range from 0.91μg·mL-1 to 12.78μg·mL-1. The concentrations of mycophenolic acid varied greatly with a ifxed-dosage. Conclusion:There is a deifnite clinical value for therapeutic drug monitoring of mycophenolate mofetil.

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目的：进一步验证丹参药材中丹酚酸类成分尤其是丹酚酸B是采后干燥的产物；了解栽培过程中土壤水分状态对新鲜和阴干后丹参药材中丹酚酸类和丹参酮类成分的影响。方法采用高效液相色谱法测定了不同土壤水分条件栽培的新鲜和采后阴干丹参样品中6种酚酸类和4种丹参酮类成分的含量。结果新鲜丹参样品中，均含有较高含量丹参酮类成分，但只有极度干旱胁迫时（土壤水势＜30％），才可检测到丹酚酸B（＜1％），且无其他酚酸类成分。阴干样品中丹酚酸类成分含量均显著增加，其中丹酚酸B含量达4．2％；丹参酮类成分也增加了30％以上。阴干后丹参中丹酚酸B及总酚酸含量与栽培过程中土壤水势呈现显著负相关。结论采后干燥有利于丹参中活性成分积累。丹参药材中丹酚酸类成分尤其是丹酚酸B是栽培和采后极度干旱（干燥）的产物，栽培过程中适度的干旱胁迫有利于药材中酚酸类成分的产生。
Objective To verify our previous findings that salvianolic acids(SAs), especially salvianolic acid B(SaB), in roots of Salvia miltiorrhiza Bge( Danshen) , were the post-harvest drying induced products;and to learn the effect of soil moisture during culti-vation on contents of 6 SAs and 4 tanshinones in fresh and dried materials.Method The contents of 6 SAs and 4 tanshinones in fresh and dried samples were determined by high performance liquid chromatography(HPLC).Results No SAs were detectable in fresh samples when soil moisture in the range of 30%~95%;whereas SaB was found in samples cultivated in extremely drought soil( mois-ture <30%) .Tanshinones components still remain at higher levels in fresh samples.But they increased significantly after drying, es-pecially,the SaB content reached 4.2%.Tanshinones components also increased by more than 30%.The contents of SaB and SAs in the drying roots showed a significant negative correlation with soil water potential during plantin

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观察丹酚酸乙对抑制乳腺癌MCF-7细胞的体外生长及凋亡作用。方法:采用MTT比色法观察丹酚酸乙对体外培养MCF-7细胞增殖抑制作用,并采用流式细胞仪检测丹酚酸乙作用于MCF-7细胞48h后细胞凋亡率和细胞周期变化。结果:丹酚酸乙能明显抑制MCF-7细胞的生长,呈剂量和时间依赖性;流式细胞仪检测结果显示,不同浓度的丹酚酸乙处理MCF-7细胞48 h后,细胞凋亡率和S期细胞的比例逐渐升高。结论:丹酚酸乙对MCF-7细胞具有明显的生长抑制和促凋亡作用。
Objective:To observe the growth inhibiting and apoptosis induced by salvianolic acid B in human breast cancer cell line MCF-7.Method:Cultivation of MCF -7 cell proliferation in vitro was deter-mined, and using flow cytometry instrument for detection apoptosis rate and cell cycle changes Dan phenolic acid b on the MCF -7 cell after 48 hours.Result: Salvianolic acid B can obviously inhibit the growth of MCF-7 cell dependent on dose and time ;Flow cytometry instrument test results showed a gradual increase of the proportion of stage S cells and apoptosis rate after adding different concentrations of acids B .Conclu-sion:Salvianolic acid B has obvious growth inhibition and promoting apoptosis effect on MCF -7 cell.

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霉酚酸是器官移植中常用的免疫抑制剂,游离霉酚酸具有药理活性,其代谢受多种因素的影响,从而产生血药浓度的个体差异。本文对影响游离霉酚酸代谢的主要因素、游离霉酚酸与不良反应的关系以及监测方法进行综述,根据患者的个体特点和疾病状态设计给药方案,为临床实现个体化给药,提高疗效、减少药品的不良反应提供参考。
Mycophenolic acid (MPA) is an immunosuppressive agent currently prescribed in organ transplantation. Free MPA has pharmacological activity. The metabolism of free MPA is affected by many factors, which manifests different plasma concentrations in different individuals. New advances including the main factors affecting the metabolism of free MPA, the relationship between free MPA and adverse drug reaction, the technology of monitoring free MPA concentration were reviewed. The dosage regimen should be established according to the patient''s individual characteristics and disease states, which could provide reference for implementing individual medication, improving clinical efficacy and decreasing the occurrence of adverse drug reactions.

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目的利用胶体金免疫层析技术对因药物滥用致使尿液中产生的四氢大麻酚酸检测试纸条进行研制。方法采用柠檬酸三钠法还原氯金酸制备胶体金。结果确立了制备四氢大麻酚酸检测试纸条的最佳条件：标记10μg/mL的抗四氢大麻酚酸单克隆抗体,将金标抗体按喷量2.0μL/cm喷涂在已处理的聚酯膜上,最后将四氢大麻酚酸-牛血清白蛋白结合物和羊抗鼠按0.5、1.0 mg/mL包被在硝酸纤维素膜(NC膜)上,经过37℃烘箱干燥16 h,组装制备四氢大麻酚酸检测试纸条。结论这种方法能在3~5 min内快速检测出尿液中残留的最小浓度为50 ng/mL的四氢大麻酚酸。
Objective To develop a tetrahydrocannabinol (THC) acid test strip by colloidal gold immu-nochromatographic technique. Methods Colloidal gold was prepared through reduction of chloroauric acid by trisodium citrate. Results The optimal conditions for preparing the THC acid test strip were as follows:10 μg/mL anti-THC acid monoclonal antibody was labeled, then the gold-labeled antibody was sprayed on a treated polyester film at a volume of 2.0 μL/cm, finally 0.5 mg/mL tetrahydrocannabinol acid-BSA combina-tion and 1.0 mg/mL goat anti-mouse antibody were used to coat the nitrocellulose (NC) membrane. After oven drying at 37 ℃ for 16 h, the tetrahydrocannabinol acid detection reagent was assembled. Conclusion The established method can rapidly detect residual THC acid at a minimum concentration of 50 ng/mL in urine in 3~5 min.

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目的建立瑞香狼毒中总酚酸含量测定方法，并比较不同溶剂的提取效率。方法乙醚脱脂，70％乙醇提取；没食子酸为对照品；分光光度法测定总酚酸含量。结果标准曲线为 A＝1.8316C-0.0505， r＝0.9990，没食子酸含量在0.095～0.47μg·ml-1范围内呈良好线性关系，精密度RSD为1.6％，稳定性RSD为3.8％，回收率为99.47％。瑞香狼毒生药中总酚酸的含量为3.29 mg·g-1，提取物中总酚酸的含量为3.26 mg·ml-1。结论70％乙醇提取效率最高。测定方法简便、快速、灵敏、准确，可作为瑞香狼毒中总酚酸含量的测定方法。
Objective To establish a method for content determination of total phenolic acid in Stellera chamaejasme,and to compare the extraction efficiencies of different solvents.Method Ether was used to degrease,70% ethanol was used to extract, spectrophotometry was to determine, and gallic acid was taken as the reference substance.Resutlt The standard curve was A=1.8316C-0.0505,r=0.9990,and the linear range was 0.095-0.47μg/ml.The RSD of the precision was 1.6%.The RSD of the stability was 3.8%.The mean recovery rate was 99.47%.The contents of total phenolic acid in Stellerachamae-jasme and the extractive of 70% ethanol were 3.29 mg/g and 3.26 mg/ml,respectively.Conclusion The best solvent was 70% ethanol.This method is simple,accurate,sensitive and suitable for determining the total phenolic acid in Sterllera chamaejasme.

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