目的比较维生素D2注射液与维生素D3注射液在治疗健康女性维生素D缺乏或不足时对血25羟维生素D水平的影响。方法选择常住成都市且年龄在40-55岁的健康女性94名,随机将其分为D2组和D3组各47例。D2组给予维生素D2注射液,每次7.5mg(30万U),每2周注射1次,共注射4次;D3组给予维生素D3注射液,每次7.5mg(30万U),每2周注射1次,共注射4次。分别于治疗前、最后1次注射后2周采静脉血测定血清25羟维生素D,血清钙、磷、镁,血清甲状旁腺素(PTH)及血清骨源性碱性磷酸酶(BAP)。结果治疗后,D2组和D3组血清25羟D水平明显升高,差异有统计学意义(P〈0.01);且治疗后D3组25羟D水平高于D2组,差异有统计学意义(P〈0.01)。治疗前后,2组血清磷、血清PTH均降低,差异有统计学意义(P〈0.01),血清钙、血清镁、血清BAP无明显变化,差异无统计学意义(P〉0.05)。未出现维生素D中毒或药物相关不良反应表现。结论维生素D针剂无论是D2还是D3治疗维生素D缺乏或不足都是有效的,但在相同用法条件下D3比D2升高血清25羟D水平的幅度更大。维生素D注射剂30万U每2周1次共4次治疗维生素D不足或缺乏是安全的。
Objective To compare the efficiency of vitamin D2 and vitamin D3 in raising the 25-hydroxyvitamin D (25(OH)D)status of female healthy adults working indoor. Methods 94 healthy women coming from Chengdu City and who were in 40 ~ 55 years old were randomly divided into Group D2(n = 47,treated with vitamin D2 injection 7. 5mg every two weeks for four times)and Group D3(n = 47,treated with D3 injection as the same way). The serum 25(OH)D,parathyroid hormone(PTH),bone alkaline phosphatase(BAP),serum calcium and phosphorus were measured before and after the inter-vention. Results After treatment,the average 25(OH)D level of Group D2、D3 increased significantly,the difference was sta-tistically significant(P 0. 05). There was no vitamin D intoxication or related adverse reactions after intervention. Conclusion vitamin D2 and vitamin D3 are both effect,but Vita-min D3 injection is more efficient than Vitamin D2 injection in raising the 25-hydroxyvitamin D status of female healthy adu