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双语推荐：LSM

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目的：探索成人肝移植术后肝脏弹性值（ LSM）与肝肾功能指标相关关系，研究其对受者术后近期预后的评估价值，为瞬时弹性成像技术在成人肝移植的应用提供依据。方法：收集浙江大学医学院附属第一医院2013年12月10日—2014年3月19日期间43例次肝移植受者临床资料及术后LSM，统计分析其相关关系；以LSM 16 kPa为界将受者分为LSM较高组和LSM较低组，比较两组间术后ICU时间、住院时间及严重并发症发生率。结果：①受者术后第1天LSM与冷缺血时间无关联，但术后第7天LSM与冷缺血时间有统计学关联（ r＝0.335， P＝0.028）。受者术后第1天LSM与术后ICU时间正相关（r＝0.488，P＝0.001），但第7天LSM与ICU时间无关联。在纳入分析的12项肝肾功能指标中，谷草转氨酶、胆汁酸及肌酐均与术后第1天和第7天LSM呈正相关。②术后第1天LSM较高组的ICU时间显著长于LSM较低组（7 d与9 d，P＝0.013），术后第1天LSM较高组住院时间显著长于LSM较低组（34 d与23 d，P＝0.023）。术后第1天LSM较高组严重并发症发生率显著高于LSM较低组（78.57％与27.59％，P＝0.002）。结论：肝脏瞬时弹性成像检测值与肝移植受者术后肝肾功能有一定关联，对肝移植受者近期预后可能有预测价值。
Objective:To evaluate the application of transient elastography in early prognosis of patients after liver transplantation.Methods:Forty-three patients receiving orthotopic liver transplant in our hospital during December 2013 and March 2014 were included in this study.Liver stiffness measurement ( LSM) was performed by FibroScan on day 1 (LSM-1) and day 7 (LSM-7) after transplantation.Patients were divided into higher LSM group (LSM>16 kPa) and lower LSM group (LSM<16 kPa).Clinical data and laboratory data were collected and the correlation of LSM with liver and renal function was analyzed.Results:The number of cases in higher LSM-1, lower LSM-7, higher LSM-7 and lower LSM-7 were 29, 11, 31 and 9, respectively.The cold ischemia time was corrected with LSM-7 (r=0.335, P=0.028), but not with LSM-1 (r=0.037, P=0.812);the length of ICU stay was positively correlated with LSM-1 (r=0.488, P=0.001), but not with LSM-7 ( r =0.213, P =0.181).LSM was positively correlated with asparta

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目的 研究成人肝移植术后应用瞬时弹性成像(TE)技术检测肝脏弹性值(LSM)评估受者早期预后的价值.方法 收集2013年12月10日至2014年3月19日间43例肝移植受者及其术后应用TE技术检测LSM的临床资料,分析受者相关资料和肝肾功能各指标与LSM的相关性.根据术后第1和第7天的LSM,每个时点将受者各分为LSM＞ 16 kPa组(高LSM组)和LSM＜ 16 kPa组(低LSM组),比较两组受者间住重症监护室(ICU)时间、住院时间及严重并发症发生率.结果 LSM与受者体质量指数、术前终末期肝病模型(MELD)评分、移植肝质量和受者体质量比、供肝热缺血时间均无明显相关性(P＞0.05);术后第1天LSM与住ICU时间呈正相关[相关系数(R)=0.488,P=0.001],术后第7天LSM与供肝冷缺血时间明显相关(R=0.335,P=0.028).术后第1天和第7天LSM与天冬氨酸转氨酶、胆汁酸及血肌酐均呈正相关,与其他肝肾功能指标均无明显相关性(P＞0.05).术后第1天高LSM组住ICU时间显著长于低LSM组(9±3和7±2d,P=0.013),术后第1天高LSM组住院时间显著长于低LSM组(34±6和23±2d,P=0.023).术后第7天高LSM组与低LSM组在住ICU时间及住院时间方面的差异均无统计学意义.术后第1天和第7天高LSM组受者严重并发症发生率均高于低LSM组(78.57％和27.59％,P
Objective To investigate the clinical value of transient elastography in adult after liver transplantation,by means of evaluating the correlation of liver stiffness measured by FibroScan with liver/renal functions.Method Forty-three patients received orthotopic liver transplant in our hospital during Dec.10,2013 and Mar.19,2014 were included in this study.Liver stiffness measurement (LSM) was performed after transplantation.Clinical data and laboratory tests including liver function and renal function were collected and analyzed.Result Bivariate correlation showed that body mass index (BMI),MELD score,graft-to-recipient weight ratio (GRWR) and warm ischemia time had no correlation with LSM.LSM at the 1st day after transplantation (LSM-1) showed no correlation with cold ischemia time,but LSM at the 7th day after transplantation (LSM-7) did,with R =0.335,P =0.028.LSM-1 showed positive correlation with the ICU time (R =0.488,P =0.001),but LSM-7 didn''t.There was significantly po

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目的 探讨胆道闭锁术后肝脏硬度测量值(liver stiffness measurement,LSM)的动态变化规律及LSM与血液学指标之间的关系,为评估胆道闭锁预后及序贯性治疗提供依据.方法 回顾性分析2012年5月至2013年3月于我院普外科就诊的85例胆道闭锁患儿LSM和血液学指标.LSM和各项血液学指标均在同一天测得,共计224份统计资料.LSM由瞬时弹性成像仪(FibroScan)测定,血液学检查指标包括血小板(PLT)、白蛋白(ALB)、碱性磷酸酶(ALP)、谷草转氨酶(AST)、谷丙转氨酶(ALT)、γ谷氨酰转肽酶(GGT)、总胆红素(TBIL)、总胆汁酸(TBA).把所收集到的224份统计资料按照接受检查的时间顺序分成12组.结果 LSM与ALP、AST、GGT、TBIL、TBA呈正相关(r分别为0.391、0.171、0.243、0.194、0.327,P值均＜0.01),与PLT、ALB呈负相关(r分别为0.267、0.249,P值均＜0.01).胆道闭锁术后LSM先上升,至术后3个月达到峰值,后逐渐下降至术后1年6个月,然后维持这一水平上下波动.术后血清ALT变化趋势与LSM基本一致.术后3个月血清TBIL和LSM均出现一个峰值.术后3个月LSM与其他各组LSM的差异均有统计学意义(P＜0.01).224份统计资料中,LSM的最大值为75.0 kPa,共出现5次,有4次出现在术后3个月,这4例患儿中的2例因胆管炎和/或顽固性腹水分别于术后6个月和8个月死亡.结论 胆道闭锁术后LSM呈动态变化,LSM与肝细胞的损伤情况及肝纤维化密切相关,血清ALT和TBIL水平可能影响LSM评价肝纤维化的准确性,胆道闭锁术后3个月LSM最高,术后3个月较高的LSM可能预示着较差的预后.
Objective To explore the dynamic changes of liver stiffness measurement (LSM) in postoperative biliary atresia (BA) and examine the relationship between LSM and hematological indicators so as to provide rationales for prognostic assessment and sequential treatment of BA,Methods A retrospective analysis was conducted for LSM and hematological indicators of 85 BA patients from May 2012 to March 2013.LSM and hematological indicators were measured on the same day with 224 statistics available.And liver stiffness was evaluated by transient elastography (FibroScan).The hematological indicators included platelet (PLT),albumin (ALB),alkaline phosphatase (ALP),alanine aminotransferase (ALT),aspartate aminotransferase (AST),y glutamyltranspeptidase (GGT),total bilirubin (TBIL) and total bile acid (TBA).According to the time sequence of inspection,224 statistics were divided into 12 groups.Results LSM was positively correlated with ALP,AST,GGT,TBIL and TBA (r =0.391,0.171,0.243,0.194,0.327 respec

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目的探讨普通人群肝脏硬度测量值（LSM）与受控衰减参数（CAP）之间的关联,为临床研究提供参考。方法在207例成功进行FibroScan检查的健康体检者,获取性别、年龄、体质量指数（BMI）和腰高比（WHtR）资料,分析其LSM和CAP的相关性。结果不同年龄人群LSM的差异无统计学意义,但在BMI≥24 kg/㎡的受试者,其LSM和CAP值分别为（4.60±1.15）kPa和（245.24±55.37）dB/m,均显著高于BMI〈24 kg/㎡的受试者[（4.25±1.23）kPa和（215.82±55.47）dB/m,P〈0.001];WHtR≥0.50的受试者LSM和CAP分别为（4.52±1.22）kPa和（247.04±57.78）dB/m,亦均高于WHtR〈0.50的受试者[（4.19±1.15）kPa和（204.65±52.25）dB/m,P〈0.05];男性受试者LSM和CAP值亦均高于女性受试者[（4.53±1.23）kPa和（4.11±1.08）dB/m对（4.11±1.08）kPa和（220.08±57.88）dB/m,P〈0.05];年龄≥50岁的受试者CAP值[（246.56±59.06）dB/m]高于年龄〈50岁的受试者[（222.88±56.60）dB/m];LSM与CAP值呈显著性正相关（r=0.26,P=0.0002）;进一步对各组人群分析发现,在BMI≥24 kg/㎡、WHtR〉0.50、男性受试者和年龄≥50岁的受试者中,LSM与CAP值呈显著性正相关（P〈0.05）,其中在BMI≥24 kg/㎡组人群,两者呈非
Objective To explore the correlation between liver stiffness measurement (LSM) and controlled attenuation parameter (CAP)in the general population. Methods A correlation of LSM to CAP was conducted in a total of 207 participants who were successfully examined by FibroScan in a general health examination,and the data including gender,age,body mass index(BMI)and waist height radio(WHtR)were recorded. Results The LSM and CAP in overweight and obese participants (BMI≥24 kg/m2)were higher than those in lean participants (BMI﹤24 kg/m2) [(4.60±1.15)kPa vs. (4.25±1.23)kPa,P﹤0.001 and(245.24±55.37)dB/m vs.(215.82±55.47) dB/m,P﹤0.001];participants with WHtR ≥0.50 had higher LSM and CAP as compared to those with WHtR ﹤0.50 [(4.52±1.22) kPa vs.(4.19±1.15) kPa,P﹤0.05 and (247.04±57.78) dB/m vs.(204.65±52.25) dB/m,P﹤0.05];male participants had higher LSM and CAP than in female [(4.53 ±1.23)kPa vs.(4.11 ±1.08) kPa,P ﹤0.05 and (4.11±1.08) dB/m vs.(220.08±57.88) dB/m,P﹤0

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目的：探讨脂质沉积性肌病（LSM ）临床特点、误诊原因及诊治。方法：分析21例L S M的临床特点、神经电生理、肌肉病理资料，并复习相关文献。结果：21例均表现为四肢近端无力、肌酶升高，肌电图呈肌源性损害或合并神经源性损害，或无异常，12例被误诊为多发性肌炎、病毒性心肌炎、重症肌无力等，经病理证实为LSM 。结论：LSM临床表现缺乏特异性，临床容易误诊，病理检查是诊断该病的主要依据。
Objective:To study the clinical and pathological features of misdiagnosised lipid storage myopa-thy(LSM ) ,and further discover the reasons of diagnosis error in this disease .Methods:The clinical data ,the results of neuro-electrophysiological and pathology of the 21 patients were analyzed and the related documents were re-viewed .Results :The 21 patients who presented myasthenia with proximal of extremities ,a rise of creatase in serum . The neuro-electrophysiological changes varied ,which could be neurogenetic changes combined with muscular abnor-malities ,as well as the 12 patients were once mistakenly diagnosed as polymyositis ,limb-girdle muscular dystrophy and myasthenia gravis .They were confirmed to be LSM by pathology .Conclusion:The clinical manifestations of LSM are nonspecifie muscle weakness which should be differentiate with related myopathy ,the definite diagnosis is de-pendent on pathological examination .

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目的：探讨瞬时弹性成像(Fibroscan)诊断慢性乙型肝炎(CHB)肝纤维化的价值。方法肝活检CHB患者115例,应用Fibroscan检测肝硬度值(LSM),同时检测相关生化指标。利用受试者工作特征曲线下面积(AUROC)评价LSM对纤维化分期的诊断价值。结果 S0、S1、S2、S3、S4的LSM(kPa)分别为(5.78±1.42)、(7.68±2.43)、(9.61±4.08)、(13.61±4.73)、(18.02±6.61),与肝纤维化分期(S)正相关(r=0.715, P<0.001)。LSM诊断S2~4、S3~4和S4的AUROC分别为0.838、0.907、0.914。当LSM界值分别为8.50 kPa(S2~4)、10.35 kPa(S3~4)、11.75 kPa(S4)时,灵敏度和特异度分别为73.7%和83.3%、90.3%和85.7%、94.0%和81.6%,阳性预测值和阴性预测值分别为83.3%和73.8%、68.3%和96.0%、47.1%和98.8%。结论 Fibroscan对S2以上的肝纤维化具有诊断价值,尤其诊断S3~4和早期肝硬化(S4)的价值较高。
Objective To investigate the value of Fibroscan in diagnosis of chronic hepatitis B (CHB) liver fibrosis. Methods There were 115 patients with CHD by liver biopsy. Fibroscan was applied in liver stiffness measurement (LSM) and related biochemical criterion. Diagnostic value of LSM for fibrosis stage was evaluated by area under receiver operating characteristic curve (AUROC). Results LSM (kPa) of S0, S1, S2, S3, and S4 were respectively (5.78±1.42), (7.68±2.43), (9.61±4.08), (13.61±4.73), and (18.02±6.61). That was positively correlated with fibrosis stage (S) (r=0.715, P<0.001). AUROC of LSM in diagnosis of S2~4, S3~4, and S4 were respectively 0.838, 0.907, and 0.914. When the LSM were at the critical values as 8.50 kPa (S2~4), 10.35 kPa (S3~4), and 11.75 kPa (S4), the sensitivity and specificity were 73.7%and 83.3%, 90.3%and 85.7%, 94.0%and 81.6%, the positive prediction rate and negative prediction rate were 83.3%and 73.8%, 68.3%and 96.0%, 47.1%and 98.8%. Conclusion Fi

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探讨采取瞬时弹性成像技术(TE)评估长期口服抗病毒药物对慢性乙型肝炎患者的肝脏硬度(LSM)变化及临床价值。方法:采用前瞻性研究方法,分析2010年1月-2012年12月收治的口服抗病毒药物治疗的慢性乙型肝炎患者60例的临床资料。结果:60例慢性乙型肝炎患者的平均治疗时间间隔为(325.6±124.1)d,治疗后的LSM显著低于治疗前[(10.3±6.1)kPa vs(17.2±11.5)kPa,P0.001],治疗后LSM改善的患者有32例(53.3%)。结论:长期口服抗病毒药物可有效改善慢性乙型肝炎患者的肝纤维化,TE是评估慢性乙型肝炎患者疾病进展的有用临床工具之一。
To explore the liver stiffness measurement (LSM) change and clinical value of patients with chronic hepatitis B treated by long-term oral antiviral drug assessed by taking transient elastography technique (TE). Methods: The clinical data of 60 patients with chronic hepatitis B treated by long-term oral antiviral drug were studied and analyzed prospectively from Jan 2010 to Dec 2012. Results: Among the 60 cases, the average treatment time interval was (325.6± 124.1) days, the LSM after the treatment was significantly lower than that in before the treatment [(10.3±6.1) kPa vs (17.2±11.5)kPa, P<0.001], and the LSM in 32 cases (53.3%) were improved after the treatment. Conclusion: The treatment of long-term oral antiviral can improve effectively liver fibrosis of chronic hepatitis B,TE is one of a useful clinical tool to assess progression of patients with chronic hepatitis B.

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目的：探讨肝硬度检测（ LSM）联合血清超敏C反应蛋白（ hs?CRP）检测在诊断乙肝肝硬化并发原发性肝癌中的价值。方法将156例未经治疗的乙肝肝硬化患者分为原发性肝癌组和肝硬化组，对两组患者的LSM值和血清hs?CRP水平进行对比分析。结果原发性肝癌组患者的LSM值为（39．72±29．05）kPa，显著高于肝硬化组[（27．81±18．46） kPa]和健康对照组[（4．25±0．74） kPa]，差异有统计学意义（P＜0．01）。原发性肝癌组患者的中位hs?CRP水平为5．81 mg／L，显著高于肝硬化组（1．78 mg／L）和健康对照组（0．38 mg／L），差异有统计学意义（P＜0．01）。 LSM值分级越高，乙肝肝硬化并发原发性肝癌患者的hs?CRP阳性率越高。在LSM值≥27．6 kPa患者中，原发性肝癌组的hs?CRP阳性率为64．2％，肝硬化组的 hs?CRP 阳性率为38．0％，差异有统计学意义（ P ＜0．01）。67例乙肝肝硬化并发原发性肝癌患者中，AFP阳性患者的LSM值和中位hs?CRP水平分别为（48．95±28．59）kPa和4．91 mg／L，甲胎蛋白（AFP）阴性患者的 LSM 值和中位 hs?CRP水平分别为（28．64±26．83）kPa和4．16 mg／L，AFP阳性患者的LSM值和中位hs?CRP水平均高于AFP阴性患者，但差异无统计学意义（P＞0．05）。结论应用LSM值分级联合血清hs?CRP检测具有潜在的诊断乙肝肝硬化并发原发性肝癌的价值。
Objective The aim of this study was to explore the diagnostic value of liver stiffness measurement combined with serum high?sensitivity C?reactive protein detection in HBV?related cirrhosis patients complicated with primary liver cancer. Methods A total of 156 previously untreated chronic hepatitis B?related cirrhosis patients and 50 healthy subjects were included in this study. The 156 patients were divided into two groups: those with primary liver cancer ( 67 cases ) and without liver cancer ( 89 cases) . The 50 healthy subjects were considered as normal control group. Liver stiffness measurement ( LSM) was conducted and serum high?sensitivity C?reactive protein ( CRP) level was assayed in all the 156 patients and 50 normal individuals, and their measurement values were statistically compared and analyzed. Results The LSM value was (39. 72 ± 29. 05)kPa in the liver cancer patients, significantly higher than the (27. 81 ± 18. 46 ) kPa in the cirrhosis alone patients and (

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采用直线步进电机(LSM)控制的汽车电动转向系统(EPS)是当前国际上的新技术之一。本文通过直线步进电机的原理、核心芯片的选用、控制系统的构建,概要研讨新型转向系统的设计要点,重点阐述直线步进电机的EPS系统架构、技术方案的确定,控制系统结构图及程序流程图,对应软硬件等对实施系统控制的影响。
Electric Power Steering(EPS)is one of the latest technologies in today''s automotive industry. The author introduces the key design aspects of LSM for vehicle EPS and covers the principles of LSM, the selection of chipsets as well as the control system framework. The focus is on the LSM system architecture for EPS, technical solution, structure of its control system and process flow, as well as the impact of corresponding hardware and software selec-tion to its application for EPS.

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本文总结了主流LSM树架构存储的数据压缩策略与不足,针对海量交通数据的存储提出了一种新的数据压缩策略,提升了读取数据的性能。
We summarizes the data compact mecha-nisms of the mainstream LSM-tree based storage ar-chitecture and their shortcomings. We proposed a new data compact mechanism for the storage of huge traffic data, which improves the data reading perfor-mance.

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