Objective Using TOPSIS method to evaluate nine indicators of single diseases quality in two wards of our hospital,then by TOPSIS method combined with the variation coefficient. Methods The cure recovery rate,average discharge and average hospitalization expenses were selected,TOPSIS method was first used to evaluate,then the variation coefficient. Results The best of nine entities was hyperbilirubinemia of newborn,the worst was premature,the results of two methods were basically same. Conclusion TOPSIS method combined with the variation coefficient can overcome the shortcomings of single evaluation method,make deep,comprehensive,reasonable and scientific evaluation results.